Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

Several studies have reported reprogramming of fibroblasts into induced cardiomyocytes; however, reprogramming into proliferative induced cardiac progenitor cells (iCPCs) remains to be accomplished. Here we report that a combination of 11 or 5 cardiac factors along with canonical Wnt and JAK/STAT si...

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Veröffentlicht in:	Cell stem cell Jg. 18; H. 3; S. 354
Hauptverfasser:	Lalit, Pratik A, Salick, Max R, Nelson, Daryl O, Squirrell, Jayne M, Shafer, Christina M, Patel, Neel G, Saeed, Imaan, Schmuck, Eric G, Markandeya, Yogananda S, Wong, Rachel, Lea, Martin R, Eliceiri, Kevin W, Hacker, Timothy A, Crone, Wendy C, Kyba, Michael, Garry, Daniel J, Stewart, Ron, Thomson, James A, Downs, Karen M, Lyons, Gary E, Kamp, Timothy J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.03.2016
Schlagworte:	Animals Cell Proliferation Cell Survival Cellular Reprogramming Cellular Reprogramming Techniques - methods Fibroblasts - cytology Fibroblasts - metabolism Mice Mice, Transgenic Myoblasts, Cardiac - cytology Myoblasts, Cardiac - metabolism Transcription Factors - biosynthesis Transcription Factors - genetics
ISSN:	1875-9777, 1875-9777
Online-Zugang:	Weitere Angaben
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