Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now known to represent a distinct member of the IFN family and plays critical roles not only in orchestrating both innate and adaptive immune responses against viruses, bacteria, and tumors, but also in...

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Vydáno v:Cold Spring Harbor perspectives in biology Ročník 11; číslo 3
Hlavní autoři: Alspach, Elise, Lussier, Danielle M, Schreiber, Robert D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.03.2019
Témata:
Animals
Antigen-Presenting Cells - metabolism
Humans
Interferon gamma Receptor
Interferon-gamma - chemistry
Interferon-gamma - physiology
Lymphocyte Activation
Macrophage Activation
Molecular Structure
Neoplasms - immunology
Receptors, Interferon - chemistry
Receptors, Interferon - metabolism
Signal Transduction
ISSN:1943-0264, 1943-0264
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Shrnutí:Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now known to represent a distinct member of the IFN family and plays critical roles not only in orchestrating both innate and adaptive immune responses against viruses, bacteria, and tumors, but also in promoting pathologic inflammatory processes. IFN-γ production is largely restricted to T lymphocytes and natural killer (NK) cells and can ultimately lead to the generation of a polarized immune response composed of T helper (Th)1 CD4 T cells and CD8 cytolytic T cells. In contrast, the temporally distinct elaboration of IFN-γ in progressively growing tumors also promotes a state of adaptive resistance caused by the up-regulation of inhibitory molecules, such as programmed-death ligand 1 (PD-L1) on tumor cell targets, and additional host cells within the tumor microenvironment. This review focuses on the diverse positive and negative roles of IFN-γ in immune cell activation and differentiation leading to protective immune responses, as well as the paradoxical effects of IFN-γ within the tumor microenvironment that determine the ultimate fate of that tumor in a cancer-bearing individual.
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a028480