Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in older adults. Most clinicians who care for the elderly are not trained to diagnose these conditions, perhaps other than typical Alzheimer's disease (AD). Each of these disorders has varied epidemiology, clini...

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Vydáno v:Cold Spring Harbor perspectives in biology Ročník 10; číslo 4
Hlavní autoři: Erkkinen, Michael G, Kim, Mee-Ohk, Geschwind, Michael D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.04.2018
Témata:
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - pathology
Brain - pathology
Diagnosis, Differential
Frontotemporal Dementia - diagnosis
Frontotemporal Dementia - epidemiology
Frontotemporal Dementia - pathology
Humans
Neurodegenerative Diseases - diagnosis
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - physiopathology
Neurology
Parkinson Disease - diagnosis
Parkinson Disease - epidemiology
Parkinson Disease - pathology
ISSN:1943-0264, 1943-0264
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Shrnutí:Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in older adults. Most clinicians who care for the elderly are not trained to diagnose these conditions, perhaps other than typical Alzheimer's disease (AD). Each of these disorders has varied epidemiology, clinical symptomatology, laboratory and neuroimaging features, neuropathology, and management. Thus, it is important that clinicians be able to differentiate and diagnose these conditions accurately. This review summarizes and highlights clinical aspects of several of the most commonly encountered neurodegenerative diseases, including AD, frontotemporal dementia (FTD) and its variants, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Huntington's disease (HD). For each condition, we provide a brief overview of the epidemiology, defining clinical symptoms and diagnostic criteria, relevant imaging and laboratory features, genetics, pathology, treatments, and differential diagnosis.
Bibliografie:ObjectType-Article-1
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a033118