Regioselectivity in the ring opening of non-activated aziridines

In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituen...

Full description

Saved in:
Bibliographic Details
Published in:Chemical Society reviews Vol. 41; no. 2; p. 643
Main Authors: Stanković, Sonja, D'hooghe, Matthias, Catak, Saron, Eum, Heesung, Waroquier, Michel, Van Speybroeck, Veronique, De Kimpe, Norbert, Ha, Hyun-Joon
Format: Journal Article
Language:English
Published: England 21.01.2012
Subjects:
Alkylation
Aziridines - chemistry
Lewis Acids - chemistry
Protons
Stereoisomerism
ISSN:1460-4744, 1460-4744
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of the electrophile and the nucleophile. This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1460-4744
1460-4744
DOI:10.1039/c1cs15140a