Small RNAs - Big Players in Plant-Microbe Interactions

Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogen...

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Vydáno v:Cell host & microbe Ročník 26; číslo 2; s. 173
Hlavní autoři: Huang, Chien-Yu, Wang, Huan, Hu, Po, Hamby, Rachael, Jin, Hailing
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 14.08.2019
Témata:
Arabidopsis - genetics
Arabidopsis - immunology
Bacteria - genetics
Bacteria - pathogenicity
Fungi - genetics
Fungi - pathogenicity
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Plant Diseases - immunology
Plant Immunity - genetics
Plant Immunity - immunology
Plants - genetics
Plants - immunology
RNA Interference - immunology
RNA, Small Interfering - genetics
RNA, Small Interfering - immunology
RNA, Small Untranslated - immunology
Symbiosis
Virulence - genetics
extracellular vesicles
small RNA
plant-microbial interaction
RNAi machinery
crop protection
cross-kingdom RNAi
ISSN:1934-6069, 1934-6069
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Popis
Shrnutí:Eukaryotic small RNAs (sRNAs) are short non-coding regulatory molecules that induce RNA interference (RNAi). During microbial infection, host RNAi machinery is highly regulated and contributes to reprogramming gene expression and balancing plant immunity and growth. While most sRNAs function endogenously, some can travel across organismal boundaries between hosts and microbes and silence genes in trans in interacting organisms, a mechanism called "cross-kingdom RNAi." During the co-evolutionary arms race between fungi and plants, some fungi developed a novel virulence mechanism, sending sRNAs as effector molecules into plant cells to silence plant immunity genes, whereas plants also transport sRNAs, mainly using extracellular vesicles, into the pathogens to suppress virulence-related genes. In this Review, we highlight recent discoveries on these key roles of sRNAs and RNAi machinery. Understanding the molecular mechanisms of sRNA biogenesis, trafficking, and RNAi machinery will help us develop innovative strategies for crop protection.
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ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2019.07.021