(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was char...

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Vydané v:	Oxidative medicine and cellular longevity Ročník 2020; číslo 2020; s. 1 - 15
Hlavní autori:	Ghazouani, Lakhdar, Mnafgui, Kais, Abid, Souhir, Ammar, Houcine, Hajji, Raouf, Tlili, Nizar, Elmufti, Afoua, Tir, Meriam, Khdhiri, Emna, Feryeni, Anwar, Allouche, Noureddine
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Publishing Corporation 2020 Hindawi John Wiley & Sons, Inc
Predmet:	Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Apoptosis Apoptosis - drug effects Benzopyrans - chemical synthesis Benzopyrans - chemistry Benzopyrans - therapeutic use Biomarkers - metabolism Coumarins - chemical synthesis Coumarins - chemistry Coumarins - therapeutic use Drug dosages Energy resources Ethanol Heart attacks Hydrazones - chemical synthesis Hydrazones - chemistry Hydrazones - therapeutic use Inflammation Inflammation - metabolism Isoproterenol - toxicity Male Molecular Structure Myocardial Infarction - chemically induced Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Treatment Outcome Tunisia
ISSN:	1942-0900, 1942-0994, 1942-0994
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