(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was char...

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Vydáno v:Oxidative medicine and cellular longevity Ročník 2020; číslo 2020; s. 1 - 15
Hlavní autoři: Ghazouani, Lakhdar, Mnafgui, Kais, Abid, Souhir, Ammar, Houcine, Hajji, Raouf, Tlili, Nizar, Elmufti, Afoua, Tir, Meriam, Khdhiri, Emna, Feryeni, Anwar, Allouche, Noureddine
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Témata:
Animals
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Benzopyrans - therapeutic use
Biomarkers - metabolism
Coumarins - chemical synthesis
Coumarins - chemistry
Coumarins - therapeutic use
Drug dosages
Energy resources
Ethanol
Heart attacks
Hydrazones - chemical synthesis
Hydrazones - chemistry
Hydrazones - therapeutic use
Inflammation
Inflammation - metabolism
Isoproterenol - toxicity
Male
Molecular Structure
Myocardial Infarction - chemically induced
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardium - metabolism
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Treatment Outcome
Tunisia
ISSN:1942-0900, 1942-0994, 1942-0994
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Shrnutí:The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Guest Editor: Ayman M. Mahmoud
ISSN:1942-0900
1942-0994
1942-0994
DOI:10.1155/2020/2432918