(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was char...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Oxidative medicine and cellular longevity Ročník 2020; číslo 2020; s. 1 - 15
Hlavní autori: Ghazouani, Lakhdar, Mnafgui, Kais, Abid, Souhir, Ammar, Houcine, Hajji, Raouf, Tlili, Nizar, Elmufti, Afoua, Tir, Meriam, Khdhiri, Emna, Feryeni, Anwar, Allouche, Noureddine
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Predmet:
Animals
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Benzopyrans - therapeutic use
Biomarkers - metabolism
Coumarins - chemical synthesis
Coumarins - chemistry
Coumarins - therapeutic use
Drug dosages
Energy resources
Ethanol
Heart attacks
Hydrazones - chemical synthesis
Hydrazones - chemistry
Hydrazones - therapeutic use
Inflammation
Inflammation - metabolism
Isoproterenol - toxicity
Male
Molecular Structure
Myocardial Infarction - chemically induced
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardium - metabolism
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Treatment Outcome
Tunisia
ISSN:1942-0900, 1942-0994, 1942-0994
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.
AbstractList The present study was directed to investigate the effect of precotreatment with (E)-N'-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.The present study was directed to investigate the effect of precotreatment with (E)-N'-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.
The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.
The present study was directed to investigate the effect of precotreatment with (E)-N ′ -(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.
Author Feryeni, Anwar
Tir, Meriam
Khdhiri, Emna
Allouche, Noureddine
Tlili, Nizar
Ghazouani, Lakhdar
Ammar, Houcine
Abid, Souhir
Hajji, Raouf
Mnafgui, Kais
Elmufti, Afoua
AuthorAffiliation 6 Internal Medicine Department, Sidi Bouzid Hospital, Ibn Eljazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia
4 Institut Supérieur des Sciences et Technologies de l'Environnement, Université de Carthage, Tunisia
8 Laboratory of Animal Physiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052, Tunisia
7 Laboratory of Organic Chemistry LR17ES08 (Natural Substances Team), Faculty of Sciences of Sfax, University of Sfax, Tunisia
1 Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia
3 Laboratoire d'Ecologie, de Biologie et de Physiologie des Organismes Aquatiques, LR18ES41, Faculté des Sciences de Tunis, Université Tunis EL Manar, 2092 Tunis, Tunisia
2 Laboratoire de Chimie Appliquée “Hétérocycles Corps Gras & Polymères”, Faculté des Sciences, Université de Sfax, 3038 Sfax, Tunisia
5 Département de Biologie (UR 13/ES25), Faculté des Sciences de Tunis, Université Tunis El-Manar, Tunis 2092, Tunisia
AuthorAffiliation_xml – name: 6 Internal Medicine Department, Sidi Bouzid Hospital, Ibn Eljazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia
– name: 2 Laboratoire de Chimie Appliquée “Hétérocycles Corps Gras & Polymères”, Faculté des Sciences, Université de Sfax, 3038 Sfax, Tunisia
– name: 8 Laboratory of Animal Physiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052, Tunisia
– name: 3 Laboratoire d'Ecologie, de Biologie et de Physiologie des Organismes Aquatiques, LR18ES41, Faculté des Sciences de Tunis, Université Tunis EL Manar, 2092 Tunis, Tunisia
– name: 7 Laboratory of Organic Chemistry LR17ES08 (Natural Substances Team), Faculty of Sciences of Sfax, University of Sfax, Tunisia
– name: 1 Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia
– name: 5 Département de Biologie (UR 13/ES25), Faculté des Sciences de Tunis, Université Tunis El-Manar, Tunis 2092, Tunisia
– name: 4 Institut Supérieur des Sciences et Technologies de l'Environnement, Université de Carthage, Tunisia
Author_xml – sequence: 1
  fullname: Ghazouani, Lakhdar
– sequence: 2
  fullname: Mnafgui, Kais
– sequence: 3
  fullname: Abid, Souhir
– sequence: 4
  fullname: Ammar, Houcine
– sequence: 5
  fullname: Hajji, Raouf
– sequence: 6
  fullname: Tlili, Nizar
– sequence: 7
  fullname: Elmufti, Afoua
– sequence: 8
  fullname: Tir, Meriam
– sequence: 9
  fullname: Khdhiri, Emna
– sequence: 10
  fullname: Feryeni, Anwar
– sequence: 11
  fullname: Allouche, Noureddine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32215169$$D View this record in MEDLINE/PubMed
BookMark eNqFks1u1DAUhSNURH9gxxpZYjMVY-rYniTeIA2jQkcqrURhwSry2DeNq8Se2k7pdMUz8UjseAs8dChQCbHylf2de8-1zm62ZZ2FLHuak5d5PpkcUELJAeWMirx6kO3kglNMhOBbdzUh29luCBeEFIzy_FG2zSjNJ3khdrLvo8N9fPLty1c8yvGoxEcr7d31ClN8eu0wPcKz1rseLGb4U7ePDmO76owGC_voNdgb1yZe3qSbMZLoxF1Bh85WNrYQzA1oNHNDL72xYzTtoTPOywgBzYNbehfBg3Udnls9qMS-WzklvTayQ3PbSK-icRYZi97LGFBMPobzFk1jBDvIaOw5Or02OlVXgM6ihxDGa2En-16upcmR1Wi6dMvoggmPs4eN7AI82Zx72cc3hx9mR_j49O18Nj3GijMWcUWFVHnTyImueFVy0qhSFlIBEUWjhK6ALmQlmZC0WCjJheaKaV4AaZqyWJRsL3t123c5LHrQCmz0squX3qSfWNVOmvrvF2va-txd1SUpBZ2I1GC0aeDd5QAh1r0JCrpOWnBDqCmrOCVFUaxnPb-HXrjB27ReosqS0QnheaKe_enozsqvFCRgfAso70Lw0NwhOanXIavXIas3IUs4vYcrE39-edrHdP8SvbgVtcZq-dn8b8TGMiQGGvmbpoQJXrIfiKjvbQ
CitedBy_id crossref_primary_10_1016_j_fbio_2024_103666
crossref_primary_10_1186_s10020_024_00854_3
crossref_primary_10_1002_tox_23385
crossref_primary_10_3390_ijms23074001
crossref_primary_10_3390_molecules27248860
crossref_primary_10_2147_IJN_S444125
crossref_primary_10_1007_s00380_025_02529_3
crossref_primary_10_3390_app122110818
crossref_primary_10_1016_j_ejphar_2025_177936
crossref_primary_10_1007_s11356_022_21422_4
crossref_primary_10_3390_foods12234351
crossref_primary_10_1007_s42250_024_01011_3
crossref_primary_10_1080_00397911_2022_2095213
crossref_primary_10_1007_s11033_020_05887_5
crossref_primary_10_1080_01480545_2021_1977025
crossref_primary_10_1111_1440_1681_13397
crossref_primary_10_3389_fphar_2021_739758
crossref_primary_10_1016_j_sajb_2025_07_006
Cites_doi 10.1007/s00281-011-0290-8
10.1111/j.1432-1033.1974.tb03714.x
10.3390/ijms161126040
10.1055/s-0043-119068
10.3949/ccjm.78a.10073
10.1016/j.biopha.2017.06.032
10.3390/genes10040261
10.1139/cjpp-2019-0085
10.1016/j.biopha.2016.11.069
10.3109/15376516.2015.1053648
10.1016/j.cbi.2015.08.001
10.1016/j.pharep.2018.06.002
10.1016/S0076-6879(84)05015-1
10.1016/j.etp.2017.06.004
10.5830/CVJA-2015-055
10.1016/j.biopha.2018.05.005
10.1016/j.phymed.2017.08.003
10.1016/0003-2697(76)90527-3
10.1016/j.bionut.2014.02.003
10.3109/14756366.2014.995180
10.1016/j.lfs.2015.05.024
10.2174/1389557516666160801094919
10.1007/s12012-015-9323-1
10.1016/j.ejphar.2018.10.034
10.1016/j.bioorg.2018.10.056
10.1016/j.bioorg.2018.01.033
10.1016/j.ejmech.2018.01.017
10.1007/s12012-015-9343-x
10.1016/j.phymed.2018.06.037
10.3390/molecules21101322
10.1016/0003-9861(59)90090-6
10.1016/j.biopha.2017.07.080
10.22074/cellj.2016.4148
10.1161/CIRCRESAHA.116.308736
10.1016/S0076-6879(84)05016-3
10.1111/jth.12534
10.2165/00003088-200544120-00003
10.1155/2016/1656450
10.1016/j.ejphar.2017.09.051
10.1016/j.arabjc.2017.05.007
10.1016/S0076-6879(78)52032-6
10.1016/j.metabol.2012.06.003
10.1007/s13105-016-0494-4
10.1016/j.pharep.2019.03.003
10.1080/13813455.2019.1657900
10.1016/j.phymed.2018.09.187
10.3892/etm.2014.1956
10.1016/S0889-8588(02)00087-4
10.2174/1573406412666160610093216
10.1016/j.phymed.2016.07.015
10.2147/VHRM.S6559
ContentType Journal Article
Copyright Copyright © 2020 Anouar Feriani et al.
Copyright © 2020 Anouar Feriani et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2020 Anouar Feriani et al. 2020
Copyright_xml – notice: Copyright © 2020 Anouar Feriani et al.
– notice: Copyright © 2020 Anouar Feriani et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
– notice: Copyright © 2020 Anouar Feriani et al. 2020
DBID ADJCN
AHFXO
RHU
RHW
RHX
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1155/2020/2432918
DatabaseName الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals
معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete
Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Hindawi Publishing Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Publicly Available Content Database
MEDLINE


CrossRef
Database_xml – sequence: 1
  dbid: RHX
  name: Hindawi Publishing Open Access
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: ProQuest Publicly Available Content
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1942-0994
Editor Mahmoud, Ayman M.
Editor_xml – sequence: 1
  givenname: Ayman M.
  surname: Mahmoud
  fullname: Mahmoud, Ayman M.
EndPage 15
ExternalDocumentID PMC7079259
32215169
10_1155_2020_2432918
1203947
Genre Journal Article
GeographicLocations Tunisia
GeographicLocations_xml – name: Tunisia
GroupedDBID ---
0R~
24P
4.4
53G
5VS
7X7
88E
8FI
8FJ
8G5
AAFWJ
AAMMB
ABUWG
ACCMX
ADBBV
ADJCN
ADRAZ
AEFGJ
AENEX
AFKRA
AGXDD
AHFXO
AHMBA
AIDQK
AIDYY
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
DIK
DWQXO
E3Z
EBD
EBS
EJD
EMOBN
F5P
FYUFA
GNUQQ
GUQSH
H13
HMCUK
HYE
IAO
IHR
INR
IPNFZ
KQ8
M1P
M2O
M48
O5R
O5S
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PUEGO
RIG
RNS
RPM
SV3
TR2
UKHRP
3V.
AAJEY
GROUPED_DOAJ
IEA
INH
ITC
M~E
RHU
RHW
RHX
AAYXX
AFFHD
ALUQN
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
K9.
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c433t-829ac1ffa5d848740fc7a6ace096fc9d8e2ba8a39a26bca49d4c3d46e0ff76b73
IEDL.DBID 7X7
ISICitedReferencesCount 17
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000522269500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1942-0900
1942-0994
IngestDate Tue Nov 04 02:00:16 EST 2025
Sun Sep 28 08:17:36 EDT 2025
Sat Nov 29 14:29:45 EST 2025
Wed Feb 19 02:29:45 EST 2025
Sat Nov 29 04:09:31 EST 2025
Tue Nov 18 22:19:05 EST 2025
Sun Jun 02 18:50:28 EDT 2024
Thu Sep 25 15:24:53 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2020
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
http://creativecommons.org/licenses/by/4.0
Copyright © 2020 Anouar Feriani et al.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c433t-829ac1ffa5d848740fc7a6ace096fc9d8e2ba8a39a26bca49d4c3d46e0ff76b73
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Guest Editor: Ayman M. Mahmoud
ORCID 0000-0002-9551-6266
0000-0003-3309-0391
OpenAccessLink https://www.proquest.com/docview/2377325041?pq-origsite=%requestingapplication%
PMID 32215169
PQID 2377325041
PQPubID 2037493
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7079259
proquest_miscellaneous_2384206667
proquest_journals_2377325041
pubmed_primary_32215169
crossref_primary_10_1155_2020_2432918
crossref_citationtrail_10_1155_2020_2432918
hindawi_primary_10_1155_2020_2432918
emarefa_primary_1203947
PublicationCentury 2000
PublicationDate 2020-00-00
PublicationDateYYYYMMDD 2020-01-01
PublicationDate_xml – year: 2020
  text: 2020-00-00
PublicationDecade 2020
PublicationPlace Cairo, Egypt
PublicationPlace_xml – name: Cairo, Egypt
– name: United States
– name: New York
PublicationTitle Oxidative medicine and cellular longevity
PublicationTitleAlternate Oxid Med Cell Longev
PublicationYear 2020
Publisher Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Publisher_xml – name: Hindawi Publishing Corporation
– name: Hindawi
– name: John Wiley & Sons, Inc
References 44
45
46
47
48
49
(54) 2016; 64
50
51
52
53
10
11
12
13
14
(32) 2015; 8
15
16
17
18
19
2
3
4
5
6
7
8
9
20
21
22
23
24
25
26
27
28
29
30
31
33
34
35
36
37
38
39
40
41
42
43
References_xml – ident: 51
  doi: 10.1007/s00281-011-0290-8
– ident: 23
  doi: 10.1111/j.1432-1033.1974.tb03714.x
– ident: 33
  doi: 10.3390/ijms161126040
– volume: 64
  start-page: 88
  issue: 2
  year: 2016
  ident: 54
  publication-title: Journal of the Association of Physicians of India
– ident: 41
  doi: 10.1055/s-0043-119068
– ident: 9
  doi: 10.3949/ccjm.78a.10073
– ident: 43
  doi: 10.1016/j.biopha.2017.06.032
– ident: 12
  doi: 10.3390/genes10040261
– ident: 21
  doi: 10.1139/cjpp-2019-0085
– ident: 5
  doi: 10.1016/j.biopha.2016.11.069
– ident: 37
  doi: 10.3109/15376516.2015.1053648
– ident: 11
  doi: 10.1016/j.cbi.2015.08.001
– ident: 17
  doi: 10.1016/j.pharep.2018.06.002
– ident: 25
  doi: 10.1016/S0076-6879(84)05015-1
– ident: 10
  doi: 10.1016/j.etp.2017.06.004
– ident: 30
  doi: 10.5830/CVJA-2015-055
– ident: 4
  doi: 10.1016/j.biopha.2018.05.005
– ident: 29
  doi: 10.1016/j.phymed.2017.08.003
– ident: 27
  doi: 10.1016/0003-2697(76)90527-3
– ident: 48
  doi: 10.1016/j.bionut.2014.02.003
– ident: 13
  doi: 10.3109/14756366.2014.995180
– ident: 3
  doi: 10.1016/j.lfs.2015.05.024
– ident: 36
  doi: 10.2174/1389557516666160801094919
– ident: 46
  doi: 10.1007/s12012-015-9323-1
– ident: 45
  doi: 10.1016/j.ejphar.2018.10.034
– ident: 15
  doi: 10.1016/j.bioorg.2018.10.056
– ident: 16
  doi: 10.1016/j.bioorg.2018.01.033
– volume: 8
  start-page: 10139
  year: 2015
  ident: 32
  publication-title: International Journal of Clinical and Experimental Pathology
– ident: 19
  doi: 10.1016/j.ejmech.2018.01.017
– ident: 39
  doi: 10.1007/s12012-015-9343-x
– ident: 2
  doi: 10.1016/j.phymed.2018.06.037
– ident: 14
  doi: 10.3390/molecules21101322
– ident: 26
  doi: 10.1016/0003-9861(59)90090-6
– ident: 40
  doi: 10.1016/j.biopha.2017.07.080
– ident: 6
  doi: 10.22074/cellj.2016.4148
– ident: 8
  doi: 10.1161/CIRCRESAHA.116.308736
– ident: 24
  doi: 10.1016/S0076-6879(84)05016-3
– ident: 50
  doi: 10.1111/jth.12534
– ident: 53
  doi: 10.2165/00003088-200544120-00003
– ident: 34
  doi: 10.1155/2016/1656450
– ident: 28
  doi: 10.1016/j.ejphar.2017.09.051
– ident: 18
  doi: 10.1016/j.arabjc.2017.05.007
– ident: 22
  doi: 10.1016/S0076-6879(78)52032-6
– ident: 38
  doi: 10.1016/j.metabol.2012.06.003
– ident: 47
  doi: 10.1007/s13105-016-0494-4
– ident: 42
  doi: 10.1016/j.pharep.2019.03.003
– ident: 20
  doi: 10.1080/13813455.2019.1657900
– ident: 44
  doi: 10.1016/j.phymed.2018.09.187
– ident: 7
  doi: 10.3892/etm.2014.1956
– ident: 52
  doi: 10.1016/S0889-8588(02)00087-4
– ident: 35
  doi: 10.2174/1573406412666160610093216
– ident: 31
  doi: 10.1016/j.phymed.2016.07.015
– ident: 49
  doi: 10.2147/VHRM.S6559
SSID ssj0063241
Score 2.3114924
Snippet The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide...
The present study was directed to investigate the effect of precotreatment with (E)-N ′ -(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide...
The present study was directed to investigate the effect of precotreatment with (E)-N'-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide...
SourceID pubmedcentral
proquest
pubmed
crossref
hindawi
emarefa
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1
SubjectTerms Animals
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Benzopyrans - therapeutic use
Biomarkers - metabolism
Coumarins - chemical synthesis
Coumarins - chemistry
Coumarins - therapeutic use
Drug dosages
Energy resources
Ethanol
Heart attacks
Hydrazones - chemical synthesis
Hydrazones - chemistry
Hydrazones - therapeutic use
Inflammation
Inflammation - metabolism
Isoproterenol - toxicity
Male
Molecular Structure
Myocardial Infarction - chemically induced
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardium - metabolism
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Treatment Outcome
SummonAdditionalLinks – databaseName: Hindawi Publishing Open Access
  dbid: RHX
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fb9MwELfYRCVeEH9Ht4GMNKRW1CJ_nMZ5LFOnToIObSCVp8hxHBopdaomG2uf-Ex8JN74FtwlaaEDBG9JfE4s3c--u_j8O0KOrAicCtsCDSglGA-EzSRYTcYjL3BjL0p8XfHMvvHHYzGZBO8akqTi9y18sHYYnluvHO46gS12yI7wMHPrfDRZL7hIOF7FVQF38LeDtc5vv9F3y_K09EzCBZij1hSD38_pn1zMm5mSv5iek3vkbuMz0kGt5PvkljYPSKuuIrl8SL53hl02_vblK-vYrOOz0TLG3BTmsLPrnDkjhgS4M22Yyz5mXToE1WRYSlR36WttVvkU5OUKnvSopOP8Smf0YmnAMSzSlY7pcY5Z2Knp0cFMZ3iiH7xTelrkFcXDQps8Y1gARIHs2yWYRoRcRk9NAnMI1U5TQ89lWdCmJhAdlOCoI8W4-UTPrtO44h6nF9WplR52BJTWJyphRCamg3k-L_MiLR6RDyfD98cj1lRwYIq7bsmEE0hlJ4n0YsGx-F-ifNmXSkPglKggFtqJpJBuIJ1-pCQPYq7cmPe1lSR-P_Ldx2TX5EY_IdQTWsUqiaSTgAcHvZQVcwEGWERSR4K3ycu1dkPV0JtjlY0srMIczwsRC2GDhTZ5sZGe17Qef5Hba4DyU8yx3ID7bXLUAOcfLzhcoypsVocidFzfd5E7zm6T55tmmNe4WSONzi9RRnCk2u_Dl_ZqEG4-BIuwjfubbeJvwXMjgJzh2y0mnVbc4UiICBHv_v-N_oDcwdv6l9Mh2S0Xl_opua2uyrRYPKtm4Q_VnC6E
  priority: 102
  providerName: Hindawi Publishing
Title (E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis
URI https://search.emarefa.net/detail/BIM-1203947
https://dx.doi.org/10.1155/2020/2432918
https://www.ncbi.nlm.nih.gov/pubmed/32215169
https://www.proquest.com/docview/2377325041
https://www.proquest.com/docview/2384206667
https://pubmed.ncbi.nlm.nih.gov/PMC7079259
Volume 2020
WOSCitedRecordID wos000522269500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1942-0994
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0063241
  issn: 1942-0900
  databaseCode: 7X7
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1942-0994
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0063241
  issn: 1942-0900
  databaseCode: BENPR
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content
  customDbUrl:
  eissn: 1942-0994
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0063241
  issn: 1942-0900
  databaseCode: PIMPY
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Research Library
  customDbUrl:
  eissn: 1942-0994
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0063241
  issn: 1942-0900
  databaseCode: M2O
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/pqrl
  providerName: ProQuest
– providerCode: PRVWIB
  databaseName: Wiley Online Library Open Access
  customDbUrl:
  eissn: 1942-0994
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0063241
  issn: 1942-0900
  databaseCode: 24P
  dateStart: 20080101
  isFulltext: true
  titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LbtpAFB21SSN103dS2jSaSqkEKqMYe4zHq4pERCCVh0grkRUaj8fFkhlTTNLAqt_UT-quf9F7jSFJ1ceiG8Tga2zLx_cxc30OIYdWAElFzYI7oJRg3Bc1JiFqMh64vhO6QeTpnGf2vdftiuHQ7xcTblnRVrn2ibmjDlOFc-RHtuN5DvJt1d5NPzNUjcLV1UJC4y7ZRtlsxLk33BRcyESeF1w-t3E-wlo3vrsu1vzWkc0d20e5jxshaUdPJHyBOLUzxqr4S_y73PPXFsobMen04f9ezSPyoMhGaWMFn8fkjjZPyM5Kn3LxlPwoNyus-_3rN1ausbLHWosQu16YzXpXKbNbDKl1J9owh50nFdqEm56gSKmu0GNtlukY7OUSfqlSSbvppU7o2cJAypnFSx3SkxT7u2NTpY2JTpArAPJe2s7SnDxipk2aMJQWUWDbWUDQRTAntG0ieDoRUDQ2dCDnGS3UhmhjDiUAkpebT7R3FYc5qzk9y9-HqeKOgP_Vu5pwRiakjWk6nadZnD0jH0-bH05arNCGYIo7zpwJ25eqFkXSDQVHWcFIebIulYaSLFJ-KLQdSCEdX9r1QEnuh1w5Ia9rK4q8euA5u2TLpEY_J9QVWoUqCqQdQW4Ieykr5AJCuwikDgQvkbdreIxUQZyO-h3JKC-gXHeEYBoVYCqRNxvr6Yow5A92ewXSrs1sy_G5VyKHBfL-8Qf7a2iNCr-Tja5xVSKvN5vBY-AykDQ6vUAbwZHEvw5H2luheHMgcO81XDktEe8WvjcGyEZ-e4uJxzkrOVItQi394u-n9ZLcx4tYTWLtk6357EK_IvfU5TzOZgf545t_igOyfdzs9gcw6tg9GPXbnf45jAat4U-q9FVs
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bT9RAFJ4gSPTFu7iKOiaQsJEJ3el02z4YsyJkN8BCBBJ4qtPpVJqU6UqXy_LkL_LBn-Sb_8JzelnAeHniwbfN9vQ2PdeZM99HyJwVQlLRsuALKOUx4XstJiFqMhE6vh05YezqAmd23e33vb09f2uCfK33wmBbZe0TC0cdZQrnyJe47bo24m213g4-M2SNwtXVmkKjVIs1PTqFki1_03sP33ee89WVneUuq1gFmBK2PWQe96VqxbF0Ik8gIV2sXNmWSkMyHys_8jQPpSdtX_J2qKTwI6HsSLS1FcduO3RtuO4NMiVQ2SfJ1FZvY2u_9v2IfV6UeL7gOANi1a32joOzDNYSFzb3kWDkUhCc1ocSfkBknD7AOvw0-V22-2vT5qUouHr3fxu_e-ROlW_TTmkg98mENg_IdMnAOXpIfiysNFn_-5dvbKHFFlzWHUXY18M42zzLGO8yBA8-1IbZbD9t0hVQ6xRpWHWTvtPmPDsAeXkO_yxSSfvZiU7p9shAUp0n5zqiyxl2sCdmkXYOdYpoCJDZ016eFfAYR9pkKUPyFAWyGyNIK9BcU9ozMQwUmgxNDP0ghzmt-JRoZwhFDsKzm0908yyJCtx2ul3s-FnEE8HCy92o8EQmop1BNhhmeZI_IrvXMs6PyaTJjH5CqONpFak4lDyG7BfOUlYkPEhevFDq0BMN8rpWx0BV0PDIUJIGRYnoOAEqb1Apb4PMj6UHJSTKH-RmKs2-EOOW7Qu3QeYqTf_HBWZrVQ4qz5oHF3rcIK_Gh8En4kKXNDo7RhlPIE1BG-40U1rN-EYQwFq4Ntwg7hV7Ggsg3vrVIyY5KHDXEUySO_7Tvz_WS3Kru7OxHqz3-mvPyG18oXLKbpZMDo-O9XNyU50Mk_zoReU8KPl43fb2E0QfsPo
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9NAFB6VliIu7JRAgUFqpUZ0VGc8ju0DQqGLGrVNI1qk9mTG4zG15I5DnS7pid_EkZ_DjX_Be17SFrGceuAWxc_b-K0zb76PkDkrhKSiZcEXUMpjwvdaTELUZCJ0fDtywtjVBc7sptvreXt7fn-CfKv3wmBbZe0TC0cdZQrnyJe47bo24m21luKqLaK_svZ28JkhgxSutNZ0GqWKbOjRKZRv-ZvuCnzrec7XVneX11nFMMCUsO0h87gvVSuOpRN5AsnpYuXKtlQaEvtY-ZGneSg9afuSt0MlhR8JZUeira04dtuha8N1b5ApSMkFnyRT_e5Wf7-OA4iDXpR7vuA4G2LVbfeOgzMO1hIXNveRbORSQJzWhxJ-QJScPsCa_DT5Xeb7awPnpYi4dvd_Hst75E6Vh9NOaTj3yYQ2D8h0ycw5ekh-LKw2We_7l69socUWXLY-irDfh3G2fZYxvs4QVPhQG2az_bRJV0HdU6Rn1U36Tpvz7ADk5Tn8s0gl7WUnOqU7IwPJdp6c64guZ9jZnphF2jnUKaIkQMZPu3lWwGYcaZOlDElVFMhujSDdQDNOadfEMFBoSjQx9L0c5rTiWaKdIRQ_CNtuPtHtsyQq8NzpTrETaBFPBMsvd6nCE5mIdgbZYJjlSf6IfLiWcX5MJk1m9BNCHU-rSMWh5DFkxXCWsiLhQVLjhVKHnmiQ17VqBqqCjEfmkjQoSkfHCVCRg0qRG2R-LD0ooVL-IDdTafmFGLdsX7gNMldp_T8uMFurdVB53Dy40OkGeTU-DL4SF8Ck0dkxyngC6QvacKeZ0oLGN4LA1sI14wZxr9jWWABx2K8eMclBgceOIJPc8Z_-_bFekltgZMFmt7fxjNzG9yln8mbJ5PDoWD8nN9XJMMmPXlR-hJKP121uPwFaKbm6
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%28E%29-N%E2%80%B2-%281-%287-Hydroxy-2-Oxo-2H-Chromen-3-Yl%29+Ethylidene%29+Benzohydrazide%2C+a+Novel+Synthesized+Coumarin%2C+Ameliorates+Isoproterenol-Induced+Myocardial+Infarction+in+Rats+through+Attenuating+Oxidative+Stress%2C+Inflammation%2C+and+Apoptosis&rft.jtitle=Oxidative+medicine+and+cellular+longevity&rft.au=Feriani%2C+Anouar&rft.au=Khdhiri%2C+Emna&rft.au=Tir%2C+Meriam&rft.au=Elmufti%2C+Afoua&rft.date=2020&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1942-0900&rft.eissn=1942-0994&rft.volume=2020&rft_id=info:doi/10.1155%2F2020%2F2432918&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1942-0900&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1942-0900&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1942-0900&client=summon