The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma

Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase‐2 (MMP‐2) and Matr...

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Veröffentlicht in:Journal of oral pathology & medicine Jg. 44; H. 5; S. 345 - 352
Hauptverfasser: Aparna, Manikkath, Rao, Lakshmi, Kunhikatta, Vijayanarayana, Radhakrishnan, Raghu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Denmark Blackwell Publishing Ltd 01.05.2015
Schlagworte:
Biomarkers, Tumor - biosynthesis
Cohort Studies
early stages
Female
Humans
Immunohistochemistry
Male
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 9 - biosynthesis
matrix metalloproteinases
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Survival Rate
tongue cancer
Tongue Neoplasms - enzymology
Tongue Neoplasms - pathology
tongue cancer
immunohistochemistry
matrix metalloproteinases
prognosis
early stages
ISSN:0904-2512, 1600-0714, 1600-0714
Online-Zugang:Volltext
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Zusammenfassung:Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase‐2 (MMP‐2) and Matrix Metalloproteinase‐9 (MMP‐9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies. Aim and objectives To study the expression of MMP‐2 and MMP‐9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects. Materials and methods Fifty‐nine tumor biopsy samples of tongue squamous cell carcinoma in T1N0M0 and T2N0M0 stages were immunostained with MMP‐2 and MMP‐9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome. Results Cytoplasmic expression of MMP‐2 correlated with that of MMP‐9 (r = 0.716, P < 0.001). Greater expression of MMP‐2 and MMP‐9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP‐9 was found to have better specificity for local recurrence, metastasis and survival. Conclusion Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures.
Bibliographie:istex:E609AE533B3CB816D7828A1FA082CF9310846960
ArticleID:JOP12245
Indian Council of Medical Research (ICMR), New Delhi, India
ark:/67375/WNG-21D53825-K
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0904-2512
1600-0714
1600-0714
DOI:10.1111/jop.12245