On the Effect of Age on the Transmission of SARS-CoV-2 in Households, Schools, and the Community

There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings. We reviewed published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, serological studies, and studies of infections in schools. Compared to younger/m...

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Veröffentlicht in:The Journal of infectious diseases Jg. 223; H. 3; S. 362
Hauptverfasser: Goldstein, Edward, Lipsitch, Marc, Cevik, Muge
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 13.02.2021
Schlagworte:
Adult
Age Factors
Aged
COVID-19 - epidemiology
COVID-19 - transmission
Databases, Factual
Disease Susceptibility
Family Characteristics
Humans
Incidence
Residence Characteristics - statistics & numerical data
SARS-CoV-2 - isolation & purification
Schools - statistics & numerical data
high schools
SARS-CoV-2
susceptibility
children
primary schools
secondary schools
young adults
seroprevalence
age
ISSN:1537-6613, 1537-6613
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Zusammenfassung:There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings. We reviewed published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, serological studies, and studies of infections in schools. Compared to younger/middle-aged adults, susceptibility to infection for children younger than 10 years is estimated to be significantly lower, while estimated susceptibility to infection in adults older than 60 years is higher. Serological studies suggest that younger adults (particularly those younger than 35 years) often have high cumulative incidence of SARS-CoV-2 infection in the community. There is some evidence that given limited control measures, SARS-CoV-2 may spread robustly in secondary/high schools, and to a lesser degree in primary schools, with class size possibly affecting that spread. There is also evidence of more limited spread in schools when some mitigation measures are implemented. Several potential biases that may affect these studies are discussed. Mitigation measures should be implemented when opening schools, particularly secondary/high schools. Efforts should be undertaken to diminish mixing in younger adults, particularly individuals aged 18-35 years, to mitigate the spread of the epidemic in the community.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1537-6613
1537-6613
DOI:10.1093/infdis/jiaa691