Confocal Raman microspectroscopy for skin characterization: a comparative study between human skin and pig skin

The present paper provides a spectral comparison between abdominal human skin (Transkin) and pig ear skin using confocal Raman microspectroscopy at 660 nm. Pig ear skin is usually utilized as a substitute for human skin for active ingredients assessment in dermatological and cosmetics fields. Herein...

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Vydáno v:Analyst (London) Ročník 137; číslo 16; s. 3673
Hlavní autoři: Tfaili, Sana, Gobinet, Cyril, Josse, Gwendal, Angiboust, Jean-François, Manfait, Michel, Piot, Olivier
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 21.08.2012
Témata:
Abdomen
Animals
Epidermis - chemistry
Female
Humans
Skin - chemistry
Spectrum Analysis, Raman
Swine
ISSN:1364-5528, 1364-5528
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Shrnutí:The present paper provides a spectral comparison between abdominal human skin (Transkin) and pig ear skin using confocal Raman microspectroscopy at 660 nm. Pig ear skin is usually utilized as a substitute for human skin for active ingredients assessment in dermatological and cosmetics fields. Herein, the comparison is made at the level of the stratum corneum (SC), the SC/epidermis junction and the viable epidermis. The 660 nm excitation source appears to be the most appropriate wavelength for such skin characterization. From Raman signatures of both skin types, a tentative assignment of vibrations was performed in the fingerprint and the high wavenumber spectral regions. Significant differences were highlighted for lipid content in in-depth spectra and for hyaluronic acid (HA) and carotenoid in SC spectra. Marked tissular variability was also revealed by certain Raman vibrations. These intrinsic molecular data probed by confocal Raman microspectroscopy have to be considered for further applications such as cutaneous drug permeation.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1364-5528
1364-5528
DOI:10.1039/c2an16292j