Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment

P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut. Rapamycin (RPM) is in the clinical trials for breast cancer treatment, but its P-gp substrate proper...

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Bibliographic Details
Published in:	Drug delivery Vol. 23; no. 7; pp. 2608 - 2616
Main Authors:	Katiyar, Sameer S., Muntimadugu, Eameema, Rafeeqi, Towseef Amin, Domb, Abraham J., Khan, Wahid
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01.09.2016
Subjects:	Alkaloids - administration & dosage Alkaloids - chemistry Alkaloids - pharmacology Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacology Benzodioxoles - administration & dosage Benzodioxoles - chemistry Benzodioxoles - pharmacology Biological Availability Breast cancer Breast Neoplasms - drug therapy Cell Line, Tumor chemosensitizer Drug Resistance, Multiple Drug Resistance, Neoplasm - drug effects Female Humans Lactic Acid - chemistry nanoparticles Nanoparticles - chemistry oral bioavailability P-glycoprotein efflux Piperidines - administration & dosage Piperidines - chemistry Piperidines - pharmacology piperine PLGA Polyglycolic Acid - chemistry Polyunsaturated Alkamides - administration & dosage Polyunsaturated Alkamides - chemistry Polyunsaturated Alkamides - pharmacology rapamycin Sirolimus - administration & dosage Sirolimus - chemistry Sirolimus - pharmacology PLGA nanoparticles piperine Breast cancer P-glycoprotein efflux oral bioavailability chemosensitizer rapamycin
ISSN:	1071-7544, 1521-0464
Online Access:	Get full text
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