SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing

Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region. Previously, we found that...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 296; p. 100356
Main Authors:	Taniguchi, Ryonosuke, Utani, Koichi, Thakur, Bhushan, Ishine, Kazuho, Aladjem, Mirit I., Shimizu, Noriaki
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2021 American Society for Biochemistry and Molecular Biology
Subjects:	extrachromosomal element gene amplification gene expression genomic instability histone deacetylase protein expression repeat-induced gene silencing sirtuin1 extrachromosomal element DIG RIGS HSR DM histone deacetylase SIRT1 repeat-induced gene silencing DSB sirtuin1 FISH genomic instability protein expression gene amplification gene expression BFB d2EGFP HDAC MAR Sirtuin1 (SIRT1) histone deacetylase (HDAC)
ISSN:	0021-9258, 1083-351X, 1083-351X
Online Access:	Get full text
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