Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Hypoglycemia is a commonly neglected complication in elderly diabetic patients, which can lead to cardiovascular events. Endothelial cell dysfunction is the primary inducer of cardiovascular events, and it is associated with hypoglycemia‐triggered cytokine release and inflammatory programmed cell de...

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Bibliographic Details
Published in:	Advanced science Vol. 12; no. 37; pp. e14530 - n/a
Main Authors:	Zuo, Deyu, Peng, Yuce, Zhao, Guozhi, Cheng, Zhesheng, Luo, Minghao, Lv, Dingyi, Chang, Shuting, Li, Na, Huang, Yanyao, Li, Xunjia, He, An
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.10.2025 Wiley
Subjects:	ANGPTL4 Animals Atherosclerosis Cardiovascular disease Cell death Coronary vessels Diabetes Diabetes Mellitus, Experimental - metabolism Diabetic Angiopathies - metabolism Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Fibrosis Gene expression Humans Hypoglycemia Hypoglycemia - complications Hypoglycemia - metabolism Inflammation Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Molecular biology Mortality Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology PANoptosis proinflammatory polarization Proteins proinflammatory polarization fibrosis ANGPTL4 PANoptosis hypoglycemia
ISSN:	2198-3844, 2198-3844
Online Access:	Get full text
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