Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell sa...
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| Vydané v: | Nature Cardiovascular Research Ročník 2; číslo 2; s. 112 - 125 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , |
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| Jazyk: | English |
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01.02.2023
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| ISSN: | 2731-0590, 2731-0590 |
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| Abstract | Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4
+
T cells, and these clonally expanded T cells expressed genes such as
CD69
,
FOS
and
FOSB
, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4
+
T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4
+
T cells. |
|---|---|
| AbstractList | Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4
+
T cells, and these clonally expanded T cells expressed genes such as
CD69
,
FOS
and
FOSB
, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4
+
T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4
+
T cells. Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4+ T cells, and these clonally expanded T cells expressed genes such as CD69, FOS and FOSB, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4+ T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4+ T cells. Depuydt and Schaftenaar et al. profile the T cell clonality in patients with atherosclerosis by performing single-cell T cell receptor sequencing on carotid artery plaques and matched peripheral blood mononuclear cell samples. The analyses showed plaque-specific clonal expansion in effector CD4+ T cells, expressing genes indicative of exposure to activating antigens, thus suggesting that atherosclerosis has an autoimmune component driven by autoreactive CD4+ T cells. Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4 T cells, and these clonally expanded T cells expressed genes such as , and , indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4 T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4 T cells. Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4+ T cells, and these clonally expanded T cells expressed genes such as CD69, FOS and FOSB, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4+ T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4+ T cells.Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4+ T cells, and these clonally expanded T cells expressed genes such as CD69, FOS and FOSB, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4+ T cells with foam cells. Finally, we integrated a published scTCR-seq dataset of the autoimmune disease psoriatic arthritis, and we report various commonalities between the two diseases. In conclusion, our data suggest that atherosclerosis has an autoimmune compondent driven by autoreactive CD4+ T cells. |
| Author | de Borst, Gert J. Kuiper, Johan Smeets, Harm J. Foks, Amanda C. Hemme, Esmeralda Delfos, Lucie Slütter, Bram Bernabé Kleijn, Mireia N. A. Pasterkamp, Gerard Goncalves, Lauren Schaftenaar, Frank H. Peeters, Judith A. H. M. Depuydt, Marie A. C. Boltjes, Arjan de Winther, Menno P. J. Prange, Koen H. M. de Jong, Maaike J. M. Wezel, Anouk Bot, Ilze de Mol, Jill |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38665903$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1172/jci.insight.149741 10.1038/s41590-019-0444-8 10.1093/nar/gkz874 10.1016/j.jconrel.2018.10.028 10.1056/NEJMoa2021372 10.1161/CIRCRESAHA.122.321116 10.1038/nri1200 10.1016/j.jacc.2017.11.055 10.1038/s41467-021-21246-9 10.1161/ATVBAHA.107.151274 10.1161/CIRCULATIONAHA.119.042863 10.4049/jimmunol.2100522 10.1002/cti2.1005 10.1111/j.1365-2567.2009.03241.x 10.1182/blood-2004-03-1184 10.18632/oncotarget.19892 10.1016/j.immuni.2017.09.008 10.1161/CIRCULATIONAHA.118.039288 10.1126/science.1254536 10.3390/cells9122665 10.1093/cvr/cvr101 10.1038/s41586-019-0969-x 10.1111/joim.12589 10.1111/bph.13802 10.1161/CIRCRESAHA.120.316770 10.1038/emm.2007.20 10.1038/s41587-020-0505-4 10.1038/s44161-022-00063-3 10.1046/j.1365-2567.2000.00964.x 10.1182/blood-2006-05-022798 10.1111/j.1365-2796.2009.02209.x 10.1038/s41586-019-1325-x 10.1161/STROKEAHA.107.496703 10.1016/j.cell.2019.05.031 10.1038/s41467-020-18513-6 10.1056/NEJMoa1707914 10.1038/nature01433 10.1111/j.1365-2133.2009.09552.x 10.1097/MOL.0000000000000025 10.1007/s10564-004-2304-6 10.1161/CIRCRESAHA.121.320090 10.1002/eji.201646837 10.1038/s41467-021-25006-7 10.1038/s41591-019-0590-4 10.1038/s41586-018-0414-6 10.1016/j.smim.2013.10.009 10.1038/ncomms11653 10.1016/j.jacc.2007.06.040 10.1038/nri3862 10.1161/01.CIR.101.25.2883 10.1038/nbt.4096 10.12688/f1000research.22139.1 |
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| Keywords | Autoimmunity Atherosclerosis |
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| References | S Jin (208_CR25) 2021; 12 D Wolf (208_CR6) 2020; 142 G La Manno (208_CR22) 2018; 560 N Benne (208_CR8) 2018; 291 G Liuzzo (208_CR21) 2007; 50 B Van Wilgenburg (208_CR36) 2016; 7 208_CR50 A Mohr (208_CR14) 2018; 7 D Cibrián (208_CR11) 2017; 47 K Padhan (208_CR17) 2010; 129 PM Ridker (208_CR1) 2017; 377 F D’Acquisto (208_CR30) 2007; 109 GHM Van Puijvelde (208_CR46) 2007; 27 TTP Seijkens (208_CR44) 2018; 71 P Dunér (208_CR47) 2011; 91 R Saigusa (208_CR40) 2022; 1 T Calandra (208_CR29) 2003; 3 SM Nidorf (208_CR2) 2020; 383 208_CR54 A Gisterå (208_CR9) 2017; 281 P Roy (208_CR7) 2022; 131 JM Schenkel (208_CR12) 2014; 346 CK Vorkas (208_CR19) 2022; 208 F Penkava (208_CR31) 2020; 11 DI Godfrey (208_CR35) 2019; 20 E Smeets (208_CR43) 2013; 24 N Borcherding (208_CR53) 2020; 9 DM Fernandez (208_CR4) 2019; 25 K Kranzer (208_CR13) 2000; 99 G Bixel (208_CR28) 2004; 104 MAC Depuydt (208_CR3) 2020; 127 M Kleinewietfeld (208_CR37) 2013; 25 IO Kwon (208_CR27) 2007; 39 A Butler (208_CR51) 2018; 36 S Stemme (208_CR5) 1995; 92 AC Foks (208_CR26) 2017; 174 BAN Verhoeven (208_CR48) 2004; 19 RR Chowdhury (208_CR10) 2022; 130 H Zhang (208_CR39) 2021; 12 WE Hellings (208_CR49) 2008; 39 T Stuart (208_CR52) 2019; 177 DV Bagaev (208_CR18) 2020; 48 X Wang (208_CR24) 2010; 162 O Khan (208_CR16) 2019; 571 G Liuzzo (208_CR20) 2000; 102 H Björkbacka (208_CR32) 2010; 268 M Wigren (208_CR41) 2019; 139 E Treiner (208_CR34) 2003; 422 I Tabas (208_CR42) 2017; 47 J Cao (208_CR55) 2019; 566 EJ Wherry (208_CR15) 2015; 15 AJ Ali (208_CR23) 2020; 9 Z Lin (208_CR33) 2017; 8 H Huang (208_CR38) 2020; 38 KY Chyu (208_CR45) 2022; 7 39196001 - Nat Cardiovasc Res. 2023 Mar;2(3):227-229. doi: 10.1038/s44161-023-00230-0 |
| References_xml | – volume: 7 start-page: e149741 year: 2022 ident: 208_CR45 publication-title: JCI Insight doi: 10.1172/jci.insight.149741 – volume: 20 start-page: 1110 year: 2019 ident: 208_CR35 publication-title: Nat. Immunol. doi: 10.1038/s41590-019-0444-8 – volume: 48 start-page: D1057 year: 2020 ident: 208_CR18 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz874 – volume: 291 start-page: 135 year: 2018 ident: 208_CR8 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.10.028 – volume: 383 start-page: 1838 year: 2020 ident: 208_CR2 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2021372 – volume: 131 start-page: 258 year: 2022 ident: 208_CR7 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.122.321116 – volume: 3 start-page: 791 year: 2003 ident: 208_CR29 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1200 – volume: 71 start-page: 527 year: 2018 ident: 208_CR44 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2017.11.055 – volume: 12 year: 2021 ident: 208_CR25 publication-title: Nat. Commun. doi: 10.1038/s41467-021-21246-9 – volume: 27 start-page: 2677 year: 2007 ident: 208_CR46 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.107.151274 – volume: 142 start-page: 1279 year: 2020 ident: 208_CR6 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.119.042863 – volume: 208 start-page: 1042 year: 2022 ident: 208_CR19 publication-title: J. Immunol. doi: 10.4049/jimmunol.2100522 – volume: 7 start-page: e1005 year: 2018 ident: 208_CR14 publication-title: Clin. Transl. Immunol. doi: 10.1002/cti2.1005 – volume: 129 start-page: 322 year: 2010 ident: 208_CR17 publication-title: Immunology doi: 10.1111/j.1365-2567.2009.03241.x – volume: 104 start-page: 3205 year: 2004 ident: 208_CR28 publication-title: Blood doi: 10.1182/blood-2004-03-1184 – volume: 8 start-page: 99312 year: 2017 ident: 208_CR33 publication-title: Oncotarget doi: 10.18632/oncotarget.19892 – volume: 47 start-page: 621 year: 2017 ident: 208_CR42 publication-title: Immunity doi: 10.1016/j.immuni.2017.09.008 – volume: 139 start-page: 2554 year: 2019 ident: 208_CR41 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.118.039288 – volume: 346 start-page: 98 year: 2014 ident: 208_CR12 publication-title: Science doi: 10.1126/science.1254536 – volume: 9 start-page: 2665 year: 2020 ident: 208_CR23 publication-title: Cells doi: 10.3390/cells9122665 – volume: 91 start-page: 528 year: 2011 ident: 208_CR47 publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvr101 – volume: 566 start-page: 496 year: 2019 ident: 208_CR55 publication-title: Nature doi: 10.1038/s41586-019-0969-x – volume: 281 start-page: 383 year: 2017 ident: 208_CR9 publication-title: J. Intern. Med. doi: 10.1111/joim.12589 – volume: 174 start-page: 3940 year: 2017 ident: 208_CR26 publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13802 – volume: 127 start-page: 1437 year: 2020 ident: 208_CR3 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.120.316770 – volume: 39 start-page: 176 year: 2007 ident: 208_CR27 publication-title: Exp. Mol. Med. doi: 10.1038/emm.2007.20 – volume: 38 start-page: 1194 year: 2020 ident: 208_CR38 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0505-4 – volume: 1 start-page: 462 year: 2022 ident: 208_CR40 publication-title: Nat. Cardiovasc. Res. doi: 10.1038/s44161-022-00063-3 – volume: 99 start-page: 170 year: 2000 ident: 208_CR13 publication-title: Immunology doi: 10.1046/j.1365-2567.2000.00964.x – volume: 109 start-page: 1095 year: 2007 ident: 208_CR30 publication-title: Blood doi: 10.1182/blood-2006-05-022798 – volume: 268 start-page: 50 year: 2010 ident: 208_CR32 publication-title: J. Intern. Med. doi: 10.1111/j.1365-2796.2009.02209.x – volume: 571 start-page: 211 year: 2019 ident: 208_CR16 publication-title: Nature doi: 10.1038/s41586-019-1325-x – volume: 39 start-page: 1029 year: 2008 ident: 208_CR49 publication-title: Stroke doi: 10.1161/STROKEAHA.107.496703 – volume: 177 start-page: 1888 year: 2019 ident: 208_CR52 publication-title: Cell doi: 10.1016/j.cell.2019.05.031 – volume: 11 year: 2020 ident: 208_CR31 publication-title: Nat. Commun. doi: 10.1038/s41467-020-18513-6 – volume: 377 start-page: 1119 year: 2017 ident: 208_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1707914 – volume: 422 start-page: 164 year: 2003 ident: 208_CR34 publication-title: Nature doi: 10.1038/nature01433 – volume: 162 start-page: 487 year: 2010 ident: 208_CR24 publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.2009.09552.x – volume: 24 start-page: 518 year: 2013 ident: 208_CR43 publication-title: Curr. Opin. Lipidol. doi: 10.1097/MOL.0000000000000025 – volume: 19 start-page: 1127 year: 2004 ident: 208_CR48 publication-title: Eur. J. Epidemiol. doi: 10.1007/s10564-004-2304-6 – volume: 92 start-page: 3893 year: 1995 ident: 208_CR5 publication-title: Med. Sci. – volume: 130 start-page: 1510 year: 2022 ident: 208_CR10 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.121.320090 – volume: 47 start-page: 946 year: 2017 ident: 208_CR11 publication-title: Eur. J. Immunol. doi: 10.1002/eji.201646837 – volume: 12 start-page: 4699 year: 2021 ident: 208_CR39 publication-title: Nat. Commun. doi: 10.1038/s41467-021-25006-7 – volume: 25 start-page: 1576 year: 2019 ident: 208_CR4 publication-title: Nat. Med. doi: 10.1038/s41591-019-0590-4 – volume: 560 start-page: 494 year: 2018 ident: 208_CR22 publication-title: Nature doi: 10.1038/s41586-018-0414-6 – ident: 208_CR50 – ident: 208_CR54 – volume: 25 start-page: 305 year: 2013 ident: 208_CR37 publication-title: Semin. Immunol. doi: 10.1016/j.smim.2013.10.009 – volume: 7 year: 2016 ident: 208_CR36 publication-title: Nat. Commun. doi: 10.1038/ncomms11653 – volume: 50 start-page: 1450 year: 2007 ident: 208_CR21 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2007.06.040 – volume: 15 start-page: 486 year: 2015 ident: 208_CR15 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3862 – volume: 102 start-page: 2883 year: 2000 ident: 208_CR20 publication-title: Circulation doi: 10.1161/01.CIR.101.25.2883 – volume: 36 start-page: 411 year: 2018 ident: 208_CR51 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4096 – volume: 9 start-page: 47 year: 2020 ident: 208_CR53 publication-title: F1000Res. doi: 10.12688/f1000research.22139.1 – reference: 39196001 - Nat Cardiovasc Res. 2023 Mar;2(3):227-229. doi: 10.1038/s44161-023-00230-0 |
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| Snippet | Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study,... |
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| SubjectTerms | Antigens Atherosclerosis Cytomegalovirus Flow cytometry Genomics Leukocytes Lymphocytes Patients Protein expression Proteins T cell receptors |
| Title | Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells |
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