Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

[Display omitted] Although flavonoid compounds have various pharmacological applications, they generally exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem, numerous promising strategies, such as the use of an absorption enhancer, structural transformation...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 570; p. 118642
Main Authors:	Zhao, Juanjuan, Yang, Jun, Xie, Yan
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 30.10.2019
Subjects:	Absorption enhancers Animals Biological Availability Drug Delivery Systems - methods Flavonoids Flavonoids - chemistry Humans Oral bioavailability Permeability - drug effects Pharmaceutical technologies Solubility - drug effects Structural transformation Water - chemistry DG LogP Daidzein (PubChem CID5281708) AUC Isoniazid (PubChem CID3767) Structural transformation BSA PVP K25 QPBS TFH IC50 NEs P-gp QU IS Kaempferol (PubChem CID5280863) AP Flavonoids BCS DCQ CDs Nicotinamide (PubChem CID936) TJs Chitosan (PubChem CID16213812) Myricetin (PubChem CID5281672) PXM SNEDDS Absorption enhancers TPD Phytic acid (PubChem CID890) TMC-MEs MRT 7,8-DHF TPGS SD KA PEG 6000 SLNs TFDM Cmax PCs Oral bioavailability Pharmaceutical technologies Cys dimer CCF NLCs TMC HP-β-CD β-Cyclodextrin (PubChem CID444041) IP6 Quercetin (PubChem CID5280343) HSYA Isorhamnetin (PubChem CID5281654) API
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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