Optimization of anastomotic configuration in CABG surgery

The geometric factors have prominent impacts on the success rate of coronary artery bypass graft (CABG). In order to clarify how to choose suitable graft‐host diameter ratio and junction angle, ANSYS9.0 was used to simulate CABG, then response surface methodology was applied to construct mathematica...

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Bibliographic Details
Published in:Communications in numerical methods in engineering Vol. 25; no. 11; pp. 1097 - 1106
Main Authors: Sui, Yunkang, Ma, Baosheng, Chu, Bo, Qiao, Aike
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2009
Wiley
Subjects:
Biological and medical sciences
Blood vessels and receptors
Fundamental and applied biological sciences. Psychology
hemodynamics
Hemodynamics. Rheology
numerical simulation
optimization
response surface methodology
Vertebrates: cardiovascular system
Human
response surface methodology
Modeling
Artery
Optimization
Bypass
Impact factor
Surgery
Response surface
Circulatory system
Hemodynamics
Shear layer
numerical simulation
Wall effect
ISSN:1069-8299, 1099-0887
Online Access:Get full text
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Summary:The geometric factors have prominent impacts on the success rate of coronary artery bypass graft (CABG). In order to clarify how to choose suitable graft‐host diameter ratio and junction angle, ANSYS9.0 was used to simulate CABG, then response surface methodology was applied to construct mathematical model, finally theory of optimization was performed to determine the optimum graft‐host diameter ratio and junction angle that could make the main factor influencing the success rate of CABG, i.e. wall shear stress gradients, smallest. The result indicates that the model of large graft‐host diameter ratio and small junction angle has better hemodynamics. It can be concluded that adopting large graft‐host diameter ratio and small junction angle with the help of clinical experiences is advisable in CABG surgery. Copyright © 2009 John Wiley & Sons, Ltd.
Bibliography:ark:/67375/WNG-DBGQRQQJ-5
National Natural Science Foundation of China - No. 10772010
Natural Science Foundation of Beijing - No. 3092004
Scientific Research of Beijing Municipal Commission of Education - No. KM200810005014
Beijing Novel Project - No. 2006B12
istex:52518A6264CF1CF360DC72C8535594D31A7FF2D9
ArticleID:CNM1310
ISSN:1069-8299
1099-0887
DOI:10.1002/cnm.1310