Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation, and drug development. Here, we present a temporal analysis of key immune mediators, cytokines, and chemokines in blood of hospitalized COVID-19 patients from serial sampling and...

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Bibliographic Details
Published in:	JCI insight Vol. 5; no. 13
Main Authors:	Zhao, Yan, Qin, Ling, Zhang, Ping, Li, Kang, Liang, Lianchun, Sun, Jianping, Xu, Bin, Dai, Yanchao, Li, Xuemei, Zhang, Chi, Peng, Yanchun, Feng, Yingmei, Li, Ang, Hu, Zhongjie, Xiang, Haiping, Ogg, Graham, Ho, Ling-Pei, McMichael, Andrew, Jin, Ronghua, Knight, Julian C., Dong, Tao, Zhang, Yonghong
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 09.07.2020
Subjects:	Adult Aged Betacoronavirus Blood Case-Control Studies Chemokine CCL5 - immunology Chemokines Coronavirus Infections - immunology Coronavirus Infections - physiopathology COVID-19 Cytokine Release Syndrome - immunology Cytokine storm Drug development Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - immunology Hospitalization Humans Illnesses Immune response Immunoassay Infections Interferon-gamma - immunology Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 10 Interleukin-10 - immunology Interleukin-6 - immunology Leukocytes Longitudinal Studies Lymphocytes Male Mann-Whitney U test Middle Aged Neutrophils Pandemics Pathology Patients Peripheral blood Pneumonia, Viral - immunology Pneumonia, Viral - physiopathology RANTES Respiratory distress syndrome SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α γ-Interferon Beijing China China COVID-19 Adaptive immunity
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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