Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion

Pancreatic α-cells exhibit oscillations in cytosolic Ca (Ca ), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate α-cell Ca oscillations have not been elucidated. As β-cell Ca oscillations are regulated in part by Ca -activated K (K ) currents, this work investig...

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Bibliographic Details
Published in:	American journal of physiology: endocrinology and metabolism Vol. 316; no. 4; p. E646
Main Authors:	Dickerson, Matthew T, Dadi, Prasanna K, Altman, Molly K, Verlage, Kenneth R, Thorson, Ariel S, Jordan, Kelli L, Vierra, Nicholas C, Amarnath, Gautami, Jacobson, David A
Format:	Journal Article
Language:	English
Published:	United States 01.04.2019
Subjects:	Alkanes - pharmacology Animals Apamin - pharmacology Calcium - metabolism Calcium Channels - metabolism Calcium Channels, L-Type - metabolism Calcium Channels, P-Type - metabolism Calcium Channels, Q-Type - metabolism Endoplasmic Reticulum - metabolism Glucagon - metabolism Glucagon-Secreting Cells - metabolism Glucose - metabolism Mice Mice, Transgenic Patch-Clamp Techniques Peptides - pharmacology Potassium Channel Blockers - pharmacology Potassium Channels, Calcium-Activated - antagonists & inhibitors Potassium Channels, Calcium-Activated - metabolism Pyrazoles - pharmacology Quinolinium Compounds - pharmacology potassium channel α-cell calcium handling glucagon secretion
ISSN:	1522-1555, 1522-1555
Online Access:	Get more information
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