TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors

In recent years, chimeric antigen receptor-modified T cell (CAR T cell) therapy has proven to be a promising approach against cancer. Nonetheless, this approach still faces multiple challenges in eliminating solid tumors, one of which being the immunosuppressive tumor microenvironment (TME). Here, w...

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Bibliographic Details
Published in:	JCI insight Vol. 5; no. 4
Main Authors:	Tang, Na, Cheng, Chen, Zhang, Xingying, Qiao, Miaomiao, Li, Na, Mu, Wei, Wei, Xiao-Fei, Han, Weidong, Wang, Haoyi
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 27.02.2020
Subjects:	Antigens Cancer Cell therapy Chimeric antigen receptors CRISPR Cytokines Cytotoxicity Genes Immunological memory Ligands Lymphocytes Lymphocytes T Memory cells Solid tumors Transforming growth factor-b Tumor microenvironment Tumors Xenografts Cancer immunotherapy Oncology Therapeutics
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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