Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emergin...

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Veröffentlicht in:	JCI insight Jg. 5; H. 12
Hauptverfasser:	Karki, Rajendra, Sharma, Bhesh Raj, Lee, Ein, Banoth, Balaji, Malireddi, R.K. Subbarao, Samir, Parimal, Tuladhar, Shraddha, Mummareddy, Harisankeerth, Burton, Amanda R., Vogel, Peter, Kanneganti, Thirumala-Devi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 18.06.2020
Schlagworte:	Apoptosis Cancer Cell death Colitis Colorectal cancer Colorectal carcinoma Homeostasis Infections Inflammasomes Inflammation Inflammatory bowel disease Inflammatory diseases Interferon Interferon regulatory factor Interferon regulatory factor 1 Kinases Medical prognosis Mutation Necroptosis Proteins Pyroptosis Transcription factors Tumorigenesis Tumors Innate immunity Oncology Immunology Colorectal cancer Cancer
ISSN:	2379-3708, 2379-3708
Online-Zugang:	Volltext
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