Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo

To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height...

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Vydáno v:	Emerging infectious diseases Ročník 29; číslo 1; s. 81 - 88
Hlavní autoři:	George, Christine Marie, Birindwa, Alves, Li, Shan, Williams, Camille, Kuhl, Jennifer, Thomas, Elizabeth, François, Ruthly, Presence, Amani Sanvura, Claude, Bisimwa Rusanga Jean, Mirindi, Patrick, Bisimwa, Lucien, Perin, Jamie, Stine, O. Colin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States U.S. National Center for Infectious Diseases 01.01.2023 Centers for Disease Control and Prevention
Témata:	Age Akkermansia muciniphila anthropometrics Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo bacteria Bacterial infections Body height Body measurements Breastfeeding & lactation Campylobacter Caregivers Child child growth Child, Preschool Children & youth Cohort analysis Complications and side effects Cryptosporidiosis Cryptosporidium Democratic Republic of the Congo - epidemiology Diarrhea Education Feces Food Gram-negative bacteria Growth Growth disorders Health aspects Households Humans Infections Laboratories Microorganisms Pathogens Pediatric research Pediatrics Physiological aspects prospective cohort studies Prospective Studies Questionnaires Regression analysis Risk factors Rural children Statistics Democratic Republic of the Congo Congo (Kinshasa) pathogenic microbes prospective cohort studies anthropometrics DRC bacteria enteric infections Akkermansia muciniphila Democratic Republic of the Congo diarrhea commensal microbes child growth
ISSN:	1080-6040, 1080-6059, 1080-6059
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Abstract	To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height and weight at baseline and growth at a 6-month follow-up. At baseline, 66% (156/236) of children had >3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001-0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient -0.03 [95% CI -0.05 to -0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth.
AbstractList	To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height and weight at baseline and growth at a 6-month follow-up. At baseline, 66% (156/236) of children had >3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001–0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient –0.03 [95% CI –0.05 to –0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth. To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height and weight at baseline and growth at a 6-month follow-up. At baseline, 66% (156/236) of children had >3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001-0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient -0.03 [95% CI -0.05 to -0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth.To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height and weight at baseline and growth at a 6-month follow-up. At baseline, 66% (156/236) of children had >3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001-0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient -0.03 [95% CI -0.05 to -0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth.
Audience	Professional Academic
Author	Mirindi, Patrick Birindwa, Alves Perin, Jamie Stine, O. Colin François, Ruthly Li, Shan George, Christine Marie Kuhl, Jennifer Bisimwa, Lucien Williams, Camille Thomas, Elizabeth Presence, Amani Sanvura Claude, Bisimwa Rusanga Jean
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SubjectTerms	Age Akkermansia muciniphila anthropometrics Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo bacteria Bacterial infections Body height Body measurements Breastfeeding & lactation Campylobacter Caregivers Child child growth Child, Preschool Children & youth Cohort analysis Complications and side effects Cryptosporidiosis Cryptosporidium Democratic Republic of the Congo - epidemiology Diarrhea Education Feces Food Gram-negative bacteria Growth Growth disorders Health aspects Households Humans Infections Laboratories Microorganisms Pathogens Pediatric research Pediatrics Physiological aspects prospective cohort studies Prospective Studies Questionnaires Regression analysis Risk factors Rural children Statistics
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Title	Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo
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