Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo

To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height...

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Vydané v:Emerging infectious diseases Ročník 29; číslo 1; s. 81 - 88
Hlavní autori: George, Christine Marie, Birindwa, Alves, Li, Shan, Williams, Camille, Kuhl, Jennifer, Thomas, Elizabeth, François, Ruthly, Presence, Amani Sanvura, Claude, Bisimwa Rusanga Jean, Mirindi, Patrick, Bisimwa, Lucien, Perin, Jamie, Stine, O. Colin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States U.S. National Center for Infectious Diseases 01.01.2023
Centers for Disease Control and Prevention
Predmet:
Age
Akkermansia muciniphila
anthropometrics
Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo
bacteria
Bacterial infections
Body height
Body measurements
Breastfeeding & lactation
Campylobacter
Caregivers
Child
child growth
Child, Preschool
Children & youth
Cohort analysis
Complications and side effects
Cryptosporidiosis
Cryptosporidium
Democratic Republic of the Congo - epidemiology
Diarrhea
Education
Feces
Food
Gram-negative bacteria
Growth
Growth disorders
Health aspects
Households
Humans
Infections
Laboratories
Microorganisms
Pathogens
Pediatric research
Pediatrics
Physiological aspects
prospective cohort studies
Prospective Studies
Questionnaires
Regression analysis
Risk factors
Rural children
Statistics
Democratic Republic of the Congo
Congo (Kinshasa)
pathogenic microbes
prospective cohort studies
anthropometrics
DRC
bacteria
enteric infections
Akkermansia muciniphila
Democratic Republic of the Congo
diarrhea
commensal microbes
child growth
ISSN:1080-6040, 1080-6059, 1080-6059
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Shrnutí:To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children <5 years of age in rural eastern Democratic Republic of the Congo. We analyzed baseline fecal specimens by quantitative PCR and measured child height and weight at baseline and growth at a 6-month follow-up. At baseline, 66% (156/236) of children had >3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001-0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient -0.03 [95% CI -0.05 to -0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2901.212118