Enhancing Hi-C contact matrices for loop detection with Capricorn: a multiview diffusion model

Motivation High-resolution Hi-C contact matrices reveal the detailed three-dimensional architecture of the genome, but high-coverage experimental Hi-C data are expensive to generate. Simultaneously, chromatin structure analyses struggle with extremely sparse contact matrices. To address this problem...

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Veröffentlicht in:	Bioinformatics (Oxford, England) Jg. 40; H. Supplement_1; S. i471 - i480
Hauptverfasser:	Fang, Tangqi, Liu, Yifeng, Woicik, Addie, Lu, Minsi, Jha, Anupama, Wang, Xiao, Li, Gang, Hristov, Borislav, Liu, Zixuan, Xu, Hanwen, Noble, William S, Wang, Sheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 28.06.2024 Oxford Publishing Limited (England)
Schlagworte:	Algorithms Availability Biological effects Chromatin Chromatin - chemistry Chromatin - metabolism Chromosomes Computational Biology - methods Humans Image enhancement Machine Learning Nucleotide sequence Probability learning Software Source code
ISSN:	1367-4803, 1367-4811, 1367-4811
Online-Zugang:	Volltext
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