Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function

Thyroid-stimulating hormone (TSH) controls thyroid growth and hormone secretion through binding to its G protein-coupled receptor (TSHR) and production of cyclic AMP (cAMP). Serum TSH is a sensitive indicator of thyroid function, and overt abnormalities in thyroid function lead to common endocrine d...

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Vydané v:	American journal of human genetics Ročník 82; číslo 6; s. 1270
Hlavní autori:	Arnaud-Lopez, Lisette, Usala, Gianluca, Ceresini, Graziano, Mitchell, Braxton D, Pilia, Maria Grazia, Piras, Maria Grazia, Sestu, Natascia, Maschio, Andrea, Busonero, Fabio, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Mulas, Antonella, Crisponi, Laura, Tanaka, Toshiko, Bandinelli, Stefania, Guralnik, Jack M, Loi, Angela, Balaci, Lenuta, Sole, Gabriella, Prinzis, Alessia, Mariotti, Stefano, Shuldiner, Alan R, Cao, Antonio, Schlessinger, David, Uda, Manuela, Abecasis, Gonçalo R, Nagaraja, Ramaiah, Sanna, Serena, Naitza, Silvia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.06.2008
Predmet:	3',5'-Cyclic-AMP Phosphodiesterases - genetics Adolescent Adult Aged Aged, 80 and over Chromosome Mapping Cyclic AMP - metabolism Feedback Female Genetic Variation Humans Linkage Disequilibrium Male Middle Aged Pituitary Gland - physiology Polymorphism, Single Nucleotide Thyroid Diseases - enzymology Thyroid Diseases - genetics Thyroid Diseases - physiopathology Thyroid Gland - enzymology Thyroid Gland - physiology Thyrotropin - blood Thyroxine - biosynthesis Triiodothyronine - biosynthesis
ISSN:	1537-6605, 1537-6605
On-line prístup:	Zistit podrobnosti o prístupe
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