The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes
Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage more likely depends on the stromal vascular fraction of adipose tissue than on the adipocyte fraction. This stromal vascular fraction can be obt...
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| Published in: | Wound repair and regeneration Vol. 24; no. 6; pp. 994 - 1003 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
Blackwell Publishing Ltd
01.11.2016
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| ISSN: | 1067-1927, 1524-475X, 1524-475X |
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| Abstract | Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage more likely depends on the stromal vascular fraction of adipose tissue than on the adipocyte fraction. This stromal vascular fraction can be obtained by dissociation of adipose tissue, either enzymatically or mechanical. Enzymatic dissociation procedures are time‐consuming and expensive. Therefore, we developed a new inexpensive mechanical dissociation procedure to obtain the stromal vascular fraction from adipose tissue in a time sparing way, which is directly available for therapeutic injection. This mechanical dissociation procedure is denoted as the fractionation of adipose tissue (FAT) procedure. The FAT procedure was performed in eleven patients. The composition of the FAT‐stromal vascular fraction was characterized by immunohistochemistry. Adipose derived stromal cells isolated from the FAT‐stromal vascular fraction were compared with adipose derived stromal cells isolated from nondissociated adipose tissue (control) for their CD‐surface marker expression, differentiation and colony forming unit capacity. Case reports demonstrated the therapeutic effect of the FAT‐stromal vascular fraction. The FAT‐stromal vascular fraction is an enrichment of extracellular matrix containing a microvasculature and culturable adipose derived stromal cells. Adipose derived stromal cells isolated from FAT‐stromal vascular fraction did not differ from adipose derived stromal cells isolated from the control group in CD‐surface marker expression, differentiation and colony forming unit capacity. The FAT procedure is a rapid effective mechanical dissociation procedure to generate FAT‐stromal vascular fraction ready for injection with all its therapeutic components of adipose tissue: it contains culturable adipose derived stromal cells embedded in their natural supportive extracellular matrix together with the microvasculature. |
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| AbstractList | Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage more likely depends on the stromal vascular fraction of adipose tissue than on the adipocyte fraction. This stromal vascular fraction can be obtained by dissociation of adipose tissue, either enzymatically or mechanical. Enzymatic dissociation procedures are time-consuming and expensive. Therefore, we developed a new inexpensive mechanical dissociation procedure to obtain the stromal vascular fraction from adipose tissue in a time sparing way, which is directly available for therapeutic injection. This mechanical dissociation procedure is denoted as the fractionation of adipose tissue (FAT) procedure. The FAT procedure was performed in eleven patients. The composition of the FAT-stromal vascular fraction was characterized by immunohistochemistry. Adipose derived stromal cells isolated from the FAT-stromal vascular fraction were compared with adipose derived stromal cells isolated from nondissociated adipose tissue (control) for their CD-surface marker expression, differentiation and colony forming unit capacity. Case reports demonstrated the therapeutic effect of the FAT-stromal vascular fraction. The FAT-stromal vascular fraction is an enrichment of extracellular matrix containing a microvasculature and culturable adipose derived stromal cells. Adipose derived stromal cells isolated from FAT-stromal vascular fraction did not differ from adipose derived stromal cells isolated from the control group in CD-surface marker expression, differentiation and colony forming unit capacity. The FAT procedure is a rapid effective mechanical dissociation procedure to generate FAT-stromal vascular fraction ready for injection with all its therapeutic components of adipose tissue: it contains culturable adipose derived stromal cells embedded in their natural supportive extracellular matrix together with the microvasculature.Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage more likely depends on the stromal vascular fraction of adipose tissue than on the adipocyte fraction. This stromal vascular fraction can be obtained by dissociation of adipose tissue, either enzymatically or mechanical. Enzymatic dissociation procedures are time-consuming and expensive. Therefore, we developed a new inexpensive mechanical dissociation procedure to obtain the stromal vascular fraction from adipose tissue in a time sparing way, which is directly available for therapeutic injection. This mechanical dissociation procedure is denoted as the fractionation of adipose tissue (FAT) procedure. The FAT procedure was performed in eleven patients. The composition of the FAT-stromal vascular fraction was characterized by immunohistochemistry. Adipose derived stromal cells isolated from the FAT-stromal vascular fraction were compared with adipose derived stromal cells isolated from nondissociated adipose tissue (control) for their CD-surface marker expression, differentiation and colony forming unit capacity. Case reports demonstrated the therapeutic effect of the FAT-stromal vascular fraction. The FAT-stromal vascular fraction is an enrichment of extracellular matrix containing a microvasculature and culturable adipose derived stromal cells. Adipose derived stromal cells isolated from FAT-stromal vascular fraction did not differ from adipose derived stromal cells isolated from the control group in CD-surface marker expression, differentiation and colony forming unit capacity. The FAT procedure is a rapid effective mechanical dissociation procedure to generate FAT-stromal vascular fraction ready for injection with all its therapeutic components of adipose tissue: it contains culturable adipose derived stromal cells embedded in their natural supportive extracellular matrix together with the microvasculature. Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage more likely depends on the stromal vascular fraction of adipose tissue than on the adipocyte fraction. This stromal vascular fraction can be obtained by dissociation of adipose tissue, either enzymatically or mechanical. Enzymatic dissociation procedures are time‐consuming and expensive. Therefore, we developed a new inexpensive mechanical dissociation procedure to obtain the stromal vascular fraction from adipose tissue in a time sparing way, which is directly available for therapeutic injection. This mechanical dissociation procedure is denoted as the fractionation of adipose tissue (FAT) procedure. The FAT procedure was performed in eleven patients. The composition of the FAT‐stromal vascular fraction was characterized by immunohistochemistry. Adipose derived stromal cells isolated from the FAT‐stromal vascular fraction were compared with adipose derived stromal cells isolated from nondissociated adipose tissue (control) for their CD‐surface marker expression, differentiation and colony forming unit capacity. Case reports demonstrated the therapeutic effect of the FAT‐stromal vascular fraction. The FAT‐stromal vascular fraction is an enrichment of extracellular matrix containing a microvasculature and culturable adipose derived stromal cells. Adipose derived stromal cells isolated from FAT‐stromal vascular fraction did not differ from adipose derived stromal cells isolated from the control group in CD‐surface marker expression, differentiation and colony forming unit capacity. The FAT procedure is a rapid effective mechanical dissociation procedure to generate FAT‐stromal vascular fraction ready for injection with all its therapeutic components of adipose tissue: it contains culturable adipose derived stromal cells embedded in their natural supportive extracellular matrix together with the microvasculature. |
| Author | Harmsen, Martin C. van der Lei, Berend Stevens, Hieronymus P. van Dongen, Joris A. Parvizi, Mojtaba |
| Author_xml | – sequence: 1 givenname: Joris A. surname: van Dongen fullname: van Dongen, Joris A. organization: Plastic Surgery Department, Bergman Clinics, Rijswijk, The Netherlands – sequence: 2 givenname: Hieronymus P. surname: Stevens fullname: Stevens, Hieronymus P. email: stevens.hp@gmail.com, stevens.hp@gmail.com organization: Plastic Surgery Department, Bergman Clinics, Rijswijk, The Netherlands – sequence: 3 givenname: Mojtaba surname: Parvizi fullname: Parvizi, Mojtaba organization: Department of Pathology & Medical Biology, University of Groningen and University Medical Centre of Groningen, Groningen, The Netherlands – sequence: 4 givenname: Berend surname: van der Lei fullname: van der Lei, Berend organization: Department of Plastic Surgery, University of Groningen and University Medical Centre of Groningen, Groningen, The Netherlands – sequence: 5 givenname: Martin C. surname: Harmsen fullname: Harmsen, Martin C. organization: Department of Pathology & Medical Biology, University of Groningen and University Medical Centre of Groningen, Groningen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27717133$$D View this record in MEDLINE/PubMed |
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minimal access cranial suspension lifting for enhanced rejuvenation publication-title: Aesthet Surg J – volume: 208 start-page: 64 issue: 1 year: 2006 end-page: 76 article-title: Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates publication-title: J Cell Physiol – volume: 9 start-page: e92444 issue: 3 year: 2014 article-title: ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays publication-title: PLoS One – volume: 109 start-page: 1292 issue: 10 year: 2004 end-page: 8 article-title: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells publication-title: Circulation – volume: 23 start-page: 2553 issue: 21 year: 2014 end-page: 67 article-title: A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics publication-title: Stem Cells Dev – volume: 129 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| Title | The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes |
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