The Activities of Heparan Sulfate and its Analogue Heparin are Dictated by Biosynthesis, Sequence, and Conformation

The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Connective Tissue Research Ročník 49; číslo 3-4; s. 140 - 144
Hlavní autori: Skidmore, Mark A., Guimond, Scott E., Rudd, Tim R., Fernig, David G., Turnbull, Jeremy E., Yates, Edwin A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Informa UK Ltd 01.01.2008
Taylor & Francis
Predmet:
Animals
Carbohydrate Conformation
Carbohydrate Sequence
Cell Line
Cell Proliferation
Conformation
Glycosaminoglycans
Heparan Sulfate
Heparin
Heparin - biosynthesis
Heparin - chemistry
Heparin - metabolism
Heparitin Sulfate - biosynthesis
Heparitin Sulfate - chemistry
Heparitin Sulfate - metabolism
Humans
Sequence
Structure
Structure-Activity Relationship
ISSN:0300-8207, 1607-8438, 1521-0456, 1607-8438
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship between structure and activity is not simple, because the structure and conformation of HS and heparin are complex. This review surveys some of the relevant findings in HS/heparin chemistry, biochemistry, and biology.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0300-8207
1607-8438
1521-0456
1607-8438
DOI:10.1080/03008200802148595