A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study

In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma s...

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Vydáno v:npj aging Ročník 11; číslo 1; s. 71
Hlavní autoři: Pribić, Tea, Das, Jayanta K., Đerek, Lovorka, Belsky, Daniel W., Orenduff, Melissa, Huffman, Kim M., Kraus, William E., Deriš, Helena, Šimunović, Jelena, Štambuk, Tamara, Frkatović-Hodžić, Azra, Kraus, Virginia B., Das, Sai Krupa, Racette, Susan B., Banskota, Nirad, Ferrucci, Luigi, Pieper, Carl, Lewis, Nathan E., Lauc, Gordan, Krishnan, Sridevi
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.08.2025
Nature Publishing Group
Témata:
631/443/7
692/53
Age
Aging
Biomarkers
Biomedical and Life Sciences
Biomedicine
C3 protein
Calories
Cell Physiology
Complement component C3
Diabetes
Disease
Epigenetics
Geriatrics/Gerontology
Glycosylation
Human Physiology
Immunoglobulin G
Intercellular adhesion molecule 1
Intervention
Investigations
Metabolism
Neurosciences
Nutrient deficiency
Pilot projects
Plasma
Polysaccharides
Proteins
Tumor necrosis factor-α
ISSN:2731-6068, 2731-6068, 2056-3973
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Abstract In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL ( p  = 0.051) and increased from 12mo to 24mo ( p  = 0.016); GlycAge decreased over the same period ( p  = 0.027). GlycAge was positively associated with TNF-α ( p  = 0.030) and ICAM-1 ( p  = 0.017). Between BL and 24mo, plasma high-branched glycans declined ( p  = 0.013), bisecting GlcNAcs increased in both plasma ( p  < 0.001) and IgG ( p  = 0.01), complement C3 protein ( p  < 0.001), C3-Man9 ( p  < 0.001), and C3-Man9Glc1C3 ( p  = 0.046) were reduced. The absence of a control group warrants cautious interpretation.
AbstractList In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.
In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.
In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL ( p  = 0.051) and increased from 12mo to 24mo ( p  = 0.016); GlycAge decreased over the same period ( p  = 0.027). GlycAge was positively associated with TNF-α ( p  = 0.030) and ICAM-1 ( p  = 0.017). Between BL and 24mo, plasma high-branched glycans declined ( p  = 0.013), bisecting GlcNAcs increased in both plasma ( p  < 0.001) and IgG ( p  = 0.01), complement C3 protein ( p  < 0.001), C3-Man9 ( p  < 0.001), and C3-Man9Glc1C3 ( p  = 0.046) were reduced. The absence of a control group warrants cautious interpretation.
ArticleNumber 71
Author Šimunović, Jelena
Kraus, William E.
Pribić, Tea
Lewis, Nathan E.
Huffman, Kim M.
Đerek, Lovorka
Krishnan, Sridevi
Das, Sai Krupa
Pieper, Carl
Belsky, Daniel W.
Banskota, Nirad
Štambuk, Tamara
Das, Jayanta K.
Deriš, Helena
Frkatović-Hodžić, Azra
Racette, Susan B.
Kraus, Virginia B.
Ferrucci, Luigi
Orenduff, Melissa
Lauc, Gordan
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  organization: School of Nutritional Sciences and Wellness, BIO5, University of Arizona
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Snippet In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years...
In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of...
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StartPage 71
SubjectTerms 631/443/7
692/53
Age
Aging
Biomarkers
Biomedical and Life Sciences
Biomedicine
C3 protein
Calories
Cell Physiology
Complement component C3
Diabetes
Disease
Epigenetics
Geriatrics/Gerontology
Glycosylation
Human Physiology
Immunoglobulin G
Intercellular adhesion molecule 1
Intervention
Investigations
Metabolism
Neurosciences
Nutrient deficiency
Pilot projects
Plasma
Polysaccharides
Proteins
Tumor necrosis factor-α
Title A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study
URI https://link.springer.com/article/10.1038/s41514-025-00254-9
https://www.ncbi.nlm.nih.gov/pubmed/40750782
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https://www.proquest.com/docview/3235725219
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Volume 11
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