A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study

In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma s...

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Bibliographic Details
Published in:npj aging Vol. 11; no. 1; p. 71
Main Authors: Pribić, Tea, Das, Jayanta K., Đerek, Lovorka, Belsky, Daniel W., Orenduff, Melissa, Huffman, Kim M., Kraus, William E., Deriš, Helena, Šimunović, Jelena, Štambuk, Tamara, Frkatović-Hodžić, Azra, Kraus, Virginia B., Das, Sai Krupa, Racette, Susan B., Banskota, Nirad, Ferrucci, Luigi, Pieper, Carl, Lewis, Nathan E., Lauc, Gordan, Krishnan, Sridevi
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.08.2025
Nature Publishing Group
Subjects:
631/443/7
692/53
Age
Aging
Biomarkers
Biomedical and Life Sciences
Biomedicine
C3 protein
Calories
Cell Physiology
Complement component C3
Diabetes
Disease
Epigenetics
Geriatrics/Gerontology
Glycosylation
Human Physiology
Immunoglobulin G
Intercellular adhesion molecule 1
Intervention
Investigations
Metabolism
Neurosciences
Nutrient deficiency
Pilot projects
Plasma
Polysaccharides
Proteins
Tumor necrosis factor-α
ISSN:2731-6068, 2731-6068, 2056-3973
Online Access:Get full text
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Summary:In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n  = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL ( p  = 0.051) and increased from 12mo to 24mo ( p  = 0.016); GlycAge decreased over the same period ( p  = 0.027). GlycAge was positively associated with TNF-α ( p  = 0.030) and ICAM-1 ( p  = 0.017). Between BL and 24mo, plasma high-branched glycans declined ( p  = 0.013), bisecting GlcNAcs increased in both plasma ( p  < 0.001) and IgG ( p  = 0.01), complement C3 protein ( p  < 0.001), C3-Man9 ( p  < 0.001), and C3-Man9Glc1C3 ( p  = 0.046) were reduced. The absence of a control group warrants cautious interpretation.
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ISSN:2731-6068
2731-6068
2056-3973
DOI:10.1038/s41514-025-00254-9