Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus Phlebovirus (Bunyaviridae)

Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and...

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Vydáno v:The American journal of tropical medicine and hygiene Ročník 76; číslo 6; s. 1194
Hlavní autoři: Xu, Fangling, Liu, Dongying, Nunes, Marcio R T, DA Rosa, Amelia P A Travassos, Tesh, Robert B, Xiao, Shu-Yuan
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2007
Témata:
Amino Acid Sequence
Antigenic Variation
Base Sequence
Complement Fixation Tests
Hemagglutination Inhibition Tests
Humans
Molecular Sequence Data
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
Rift Valley Fever - virology
Rift Valley fever virus - genetics
Rift Valley fever virus - immunology
RNA, Viral - chemistry
RNA, Viral - genetics
Sequence Alignment
ISSN:0002-9637
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Shrnutí:Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.
Bibliografie:ObjectType-Article-1
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ISSN:0002-9637
DOI:10.4269/ajtmh.2007.76.1194