A 17q12 allele is associated with altered NK cell subsets and function

NK cells play an important role in innate immunity. A previous genome-wide association study demonstrated an association between a 17q12 allele (rs9916629(C)) and lower frequency of CD3(-)CD56(+) NK cells in peripheral blood. We performed an analysis that not only replicates the original result of t...

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Vydáno v:	The Journal of immunology (1950) Ročník 188; číslo 7; s. 3315
Hlavní autoři:	Xia, Zongqi, Liu, Qingquan, Berger, Christoph T, Keenan, Brendan T, Kaliszewska, Anna, Cheney, Patrick C, Srivastava, Gyan P, Castillo, Irene Wood, De Jager, Philip L, Alter, Galit
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2012
Témata:	Adult Alleles Antibody-Dependent Cell Cytotoxicity CD56 Antigen - analysis Cell Separation Chemokine CCL4 - secretion Chromosome Mapping Chromosomes, Human, Pair 17 - genetics Cytotoxicity, Immunologic Female Flow Cytometry Humans Immunophenotyping Killer Cells, Natural - classification Killer Cells, Natural - immunology Killer Cells, Natural - secretion Lymphocyte Count Lymphopoiesis Male NK Cell Lectin-Like Receptor Subfamily C - analysis Polymorphism, Single Nucleotide Transcription, Genetic - immunology
ISSN:	1550-6606, 1550-6606
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