Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review

Due to change in lifestyle and food habits, people are more at risk of diet-related diseases and cancers. It is also established that dietary modifications significantly reduce the risk of diseases. Nutrigenomics is relatively fresh discipline, but possess an enormous potential that can apply for pr...

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Vydané v:Critical reviews in food science and nutrition Ročník 60; číslo 8; s. 1375 - 1387
Hlavní autori: Nasir, Ayesha, Bullo, Mir. M. Hassan, Ahmed, Zaheer, Imtiaz, Aysha, Yaqoob, Eesha, Safdar, Mahpara, Ahmed, Hajra, Afreen, Asma, Yaqoob, Sanabil
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Taylor & Francis 27.04.2020
Taylor & Francis Ltd
Predmet:
Anticancer properties
antineoplastic activity
Bioactive compounds
bioactive food compounds
biochemical pathways
Breast
Cancer
Carcinoma
chromatin
Chromatin remodeling
Deoxyribonucleic acid
Diet
diet and disease
diet-related diseases
dietary minerals
disease occurrence
Disease prevention
DNA
DNA Methylation
DNA Repair - genetics
eating habits
Epigenesis, Genetic
Epigenetics
Esophagus
Fatty acids
Folic acid
Food
Food habits
Food preferences
Gene expression
gene interaction
health care workers
Health risks
Humans
lifestyle
Lung cancer
lung neoplasms
Medical personnel
Metabolic response
Minerals
neoplasm cells
Neoplasms - genetics
Neoplasms - prevention & control
Nutrients
Nutrigenomics
Omega-3 fatty acids
Pancreas
Pathogenesis
Polyphenols
Prostate
risk
risk reduction
Selenium
Vitamins
zinc
Nutrigenomics
cancer
diet and disease
epigenetics
ISSN:1040-8398, 1549-7852, 1549-7852
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Shrnutí:Due to change in lifestyle and food habits, people are more at risk of diet-related diseases and cancers. It is also established that dietary modifications significantly reduce the risk of diseases. Nutrigenomics is relatively fresh discipline, but possess an enormous potential that can apply for prevention and management of certain carcinomas and diseases. This review enables us to generate useful information for scientists and health professionals regarding the role of Nutrigenomics in the prevention of diet and lifestyle-related diseases like cancer. It influences health conditions of individuals and susceptibility of disease by defining the metabolic response and gene expression. Epigenetic modifications can perform a significant role in disease occurrence and pathogenesis. DNA methylation and chromatin remodeling are the most common epigenetic mechanisms. Omega 3 fatty acids are the best example of nutrients and gene interaction not involving DNA methylation while certain bioactive food compounds have a proven role in cancer prevention through an epigenetic mechanism. Dietary polyphenols substantially take part in prevention of oral, breast, skin, esophageal, colorectal, prostate, pancreatic and lung cancers. Moreover, minerals and vitamins involve regulatory processes. Zinc, Selenium and folate involve in DNA repairing process have anticancer properties. Consumption of multivitamins prevents methylation of cancer cells.
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ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2019.1571480