Kaempferol: A flavonoid with wider biological activities and its applications

Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted...

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Vydané v:	Critical reviews in food science and nutrition Ročník ahead-of-print; číslo ahead-of-print; s. 1 - 25
Hlavní autori:	Bangar, Sneh Punia, Chaudhary, Vandana, Sharma, Nitya, Bansal, Vasudha, Ozogul, Fatih, Lorenzo, Jose M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 06.11.2023 Taylor & Francis Ltd
Predmet:	Anticancer properties antioxidants bioactivities Bioavailability Biological activity Biosynthesis cell structures Cytology Flavonoids Flavonols food science hepatoprotective effect humans Kaempferol Lipid peroxidation Lipids mechanism of action Neuroprotection nutrition Oxidation toxicology water solubility Flavonoids bioavailability biosynthesis flavonols bioactivities
ISSN:	1040-8398, 1549-7852, 1549-7852
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Abstract	Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.
AbstractList	Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications. Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.
Author	Bangar, Sneh Punia Sharma, Nitya Lorenzo, Jose M. Ozogul, Fatih Bansal, Vasudha Chaudhary, Vandana
Author_xml	– sequence: 1 givenname: Sneh Punia surname: Bangar fullname: Bangar, Sneh Punia organization: Department of Food, Nutrition and Packaging Sciences, Clemson University – sequence: 2 givenname: Vandana surname: Chaudhary fullname: Chaudhary, Vandana organization: College of Dairy Science and Technology, Lala Lajpat Rai University of Veterinary and Animal Sciences – sequence: 3 givenname: Nitya surname: Sharma fullname: Sharma, Nitya organization: Food Customization Research Lab, Centre for Rural Development and Technology, Indian Institute of Technology – sequence: 4 givenname: Vasudha surname: Bansal fullname: Bansal, Vasudha organization: Department of Foods and Nutrition, Government of Home Science College – sequence: 5 givenname: Fatih orcidid: 0000-0002-0655-0105 surname: Ozogul fullname: Ozogul, Fatih organization: Department of Seafood Processing Technology, Faculty of Fisheries, University of Cukurova – sequence: 6 givenname: Jose M. orcidid: 0000-0002-7725-9294 surname: Lorenzo fullname: Lorenzo, Jose M. organization: Área de Tecnología de los Alimentos, Facultad de Ciencias de Ourense, Universidade de Vigo
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Snippet	Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human...
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SubjectTerms	Anticancer properties antioxidants bioactivities Bioavailability Biological activity Biosynthesis cell structures Cytology Flavonoids Flavonols food science hepatoprotective effect humans Kaempferol Lipid peroxidation Lipids mechanism of action Neuroprotection nutrition Oxidation toxicology water solubility
Title	Kaempferol: A flavonoid with wider biological activities and its applications
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