Kaempferol: A flavonoid with wider biological activities and its applications

Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition Vol. ahead-of-print; no. ahead-of-print; pp. 1 - 25
Main Authors: Bangar, Sneh Punia, Chaudhary, Vandana, Sharma, Nitya, Bansal, Vasudha, Ozogul, Fatih, Lorenzo, Jose M.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 06.11.2023
Taylor & Francis Ltd
Subjects:
Anticancer properties
antioxidants
bioactivities
Bioavailability
Biological activity
Biosynthesis
cell structures
Cytology
Flavonoids
Flavonols
food science
hepatoprotective effect
humans
Kaempferol
Lipid peroxidation
Lipids
mechanism of action
Neuroprotection
nutrition
Oxidation
toxicology
water solubility
Flavonoids
bioavailability
biosynthesis
flavonols
bioactivities
ISSN:1040-8398, 1549-7852, 1549-7852
Online Access:Get full text
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Summary:Kaempferol and its derivatives are naturally occurring phytochemicals with promising bioactivities. This flavonol can reduce the lipid oxidation in the human body, prevent the organs and cell structure from deterioration and protect their functional integrity. This review has extensively highlighted the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol. However, poor water solubility and low bioavailability of kaempferol greatly limit its applications. The utilization of advanced delivery systems can improve its stability, efficacy, and bioavailability. This is the first review that aimed to comprehensively collate some of the vital information published on biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. Besides, it provides insights into the future direction on the improvement of bioavailability of kaempferol for wide applications.
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ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2022.2067121