Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer c...

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Bibliographic Details
Published in:	Nature cell biology Vol. 20; no. 8; pp. 966 - 978
Main Authors:	Er, Ekrem Emrah, Valiente, Manuel, Ganesh, Karuna, Zou, Yilong, Agrawal, Saloni, Hu, Jing, Griscom, Bailey, Rosenblum, Marc, Boire, Adrienne, Brogi, Edi, Giancotti, Filippo G., Schachner, Melitta, Malladi, Srinivas, Massagué, Joan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Subjects:	13/1 13/105 13/106 13/109 13/31 13/89 13/95 14/1 14/19 14/35 59 59/5 631/67 631/67/322 631/80/79/2066 631/80/86 82 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - secondary Cancer Cancer Research Capillaries Capillaries - metabolism Capillaries - pathology Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell Biology Cell Communication Cell Movement Cell Proliferation Cell Shape Colonization Developmental Biology Female HCT116 Cells HEK293 Cells Humans ILK protein Infiltration Integrin beta1 - genetics Integrin beta1 - metabolism Invasiveness Kinases Latency Life Sciences Male Mechanotransduction Mechanotransduction, Cellular Metastases Metastasis Mice, Inbred C57BL Mice, Inbred NOD Molecular chains Neural cell adhesion molecule Neural Cell Adhesion Molecule L1 - genetics Neural Cell Adhesion Molecule L1 - metabolism Organs Pericytes Pericytes - metabolism Pericytes - pathology Phosphoproteins - genetics Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Signaling Spreading Stem Cells Time Factors Tissue Culture Techniques Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Tumor Microenvironment Yes-associated protein
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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