Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity

Heme oxygenase-1 (HO-1) is a stress response protein and its induction is associated with protection against oxidative stress. Cell survival during exposure to environmental stresses is associated with elevation of HO-1. Telomerase plays an important role in cell proliferation and immortalization. O...

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Bibliographic Details
Published in:	The international journal of biochemistry & cell biology Vol. 34; no. 12; pp. 1619 - 1628
Main Authors:	Ghattas, Maivel H, Chuang, Linus T, Kappas, Attallah, Abraham, Nader G
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.12.2002
Subjects:	Blotting, Western Carcinoma, Hepatocellular Cell Survival - drug effects Enzyme Induction - drug effects Heat-Shock Proteins - metabolism Heme oxygenase Heme Oxygenase (Decyclizing) - antagonists & inhibitors Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Hemin - pharmacology HepG2 Humans Oxidants - pharmacology Oxidative stress Oxidative Stress - drug effects Protective Agents - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Telomerase Telomerase - genetics Telomerase - metabolism Tin Compounds - pharmacology Tumor Cells, Cultured Oxidative stress SnCl 2, stannic chloride G3PDH, glyceraldhyde-3-phosphate dehydrogenase SnMP, stannic mesoporphyrin TRAP, telomerase repeat amplification protocol Heme oxygenase HO, heme oxygenase HepG2 RT, reverse transcriptase hTERT, human telomerase reverse transcriptase Telomerase
ISSN:	1357-2725, 1878-5875
Online Access:	Get full text
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