Ion selectivity of scorpion toxin-induced pores in cardiac myocytes

The lytic activity of parabutoporin (PP) and opistoporin 1 (OP1) on mammalian and bacterial membranes have been described. We investigated pore-formation and ion selectivity in cardiac myocytes by measuring the whole cell leak current by means of the patch clamp technique. Pore formation was observe...

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Bibliographic Details
Published in:	Peptides (New York, N.Y. : 1980) Vol. 27; no. 1; pp. 55 - 61
Main Authors:	Elgar, Dale, Verdonck, Fons, Grobler, Anne, Fourie, Carla, du Plessis, Johan
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 2006 Elsevier Science
Subjects:	Animals Antimicrobial Antimicrobial Cationic Peptides - toxicity Biological and medical sciences Cations, Divalent - metabolism Cations, Monovalent - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Fundamental and applied biological sciences. Psychology Gramicidin - pharmacology Ion selectivity Membrane Potentials - drug effects Membrane Potentials - physiology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Peptides Pore-forming Rats Rats, Sprague-Dawley Scorpion Scorpion Venoms - toxicity Scorpions - physiology Venom Vertebrates: endocrinology Antimicrobial Peptides Scorpion Pore-forming Venom Ion selectivity Heart Toxin Pore-forming Peptides Antimicrobial Ion selectivity Scorpion Venom Ions Selectivity Circulatory system Antibacterial agent Antimicrobial agent Myocyte
ISSN:	0196-9781, 1873-5169
Online Access:	Get full text
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