Doxorubicin–Trabectedin with Trabectedin Maintenance in Leiomyosarcoma

Among patients with leiomyosarcoma, a combination of doxorubicin and trabectedin with prolonged trabectedin maintenance therapy led to longer overall survival than doxorubicin alone (median, 33 vs. 24 months).

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Veröffentlicht in:	The New England journal of medicine Jg. 391; H. 9; S. 789 - 799
Hauptverfasser:	Pautier, Patricia, Italiano, Antoine, Piperno-Neumann, Sophie, Chevreau, Christine, Penel, Nicolas, Firmin, Nelly, Boudou-Rouquette, Pascaline, Bertucci, François, Lebrun-Ly, Valérie, Ray-Coquard, Isabelle, Kalbacher, Elsa, Bompas, Emmanuelle, Collard, Olivier, Isambert, Nicolas, Guillemet, Cécile, Rios, Maria, Le Cesne, Axel, Balleyguier, Corinne, Archambaud, Baptiste, Duffaud, Florence
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Massachusetts Medical Society 05.09.2024
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Cancer Chemotherapy Combination therapy Disease control Doxorubicin Doxorubicin - administration & dosage Doxorubicin - adverse effects Female Gynecologic Oncology Gynecology Hematology Humanities and Social Sciences Humans Kaplan-Meier Estimate Leiomyosarcoma - drug therapy Leiomyosarcoma - mortality Leiomyosarcoma - pathology Life Sciences Maintenance Chemotherapy Medical prognosis Metastases Metastasis Methodology Methods and statistics Middle Aged Neoplasm Staging Neutropenia Obstetrics Oncology Other Statistics Patients Progression-Free Survival Sarcoma Soft Tissue Neoplasms - drug therapy Soft Tissue Neoplasms - mortality Soft Tissue Neoplasms - pathology Statistical analysis Statistics Survival Survival Analysis Trabectedin - administration & dosage Trabectedin - adverse effects Treatments in Oncology Uterine Neoplasms - drug therapy Uterine Neoplasms - mortality Uterine Neoplasms - pathology Uterus
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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