Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)

The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H 2O 2, promoted MICA (2.2-fold) and MICB (3....

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Vydané v:	Biochimica et biophysica acta Ročník 1526; číslo 1; s. 10 - 12
Hlavní autori:	Yamamoto, Kazuo, Fujiyama, Yoshihide, Andoh, Akira, Bamba, Tadao, Okabe, Hidetoshi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 03.04.2001
Predmet:	Caco-2 Cells - metabolism Gene Expression Regulation H 2O 2 Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Humans Hydrogen Peroxide Membrane Proteins - metabolism MICA MICB Oxidative Stress Reverse Transcriptase Polymerase Chain Reaction H 2O 2 Oxidative stress MICA MICB
ISSN:	0304-4165, 0006-3002, 1872-8006
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Shrnutí:	The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H 2O 2, promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-4165 0006-3002 1872-8006
DOI:	10.1016/S0304-4165(01)00099-X