Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)

The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H 2O 2, promoted MICA (2.2-fold) and MICB (3....

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Published in:Biochimica et biophysica acta Vol. 1526; no. 1; pp. 10 - 12
Main Authors: Yamamoto, Kazuo, Fujiyama, Yoshihide, Andoh, Akira, Bamba, Tadao, Okabe, Hidetoshi
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 03.04.2001
Subjects:
Caco-2 Cells - metabolism
Gene Expression Regulation
H 2O 2
Histocompatibility Antigens Class I - biosynthesis
Histocompatibility Antigens Class I - genetics
Humans
Hydrogen Peroxide
Membrane Proteins - metabolism
MICA
MICB
Oxidative Stress
Reverse Transcriptase Polymerase Chain Reaction
H 2O 2
Oxidative stress
MICA
MICB
ISSN:0304-4165, 0006-3002, 1872-8006
Online Access:Get full text
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Summary:The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H 2O 2, promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR.
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ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/S0304-4165(01)00099-X