Increased neutrophil percentage-to-albumin ratio is associated with all-cause mortality in patients with severe sepsis or septic shock

There has been no study exploring the prognostic values of neutrophil percentage-to-albumin ratio (NPAR). We hypothesised that NPAR is a novel marker of inflammation and is associated with all-cause mortality in patients with severe sepsis or septic shock. Patient data were extracted from the MIMIC-...

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Published in:Epidemiology and infection Vol. 148; p. e87
Main Authors: Gong, Yuqiang, Li, Diwen, Cheng, Bihuan, Ying, Binyu, Wang, Benji
Format: Journal Article
Language:English
Published: England Cambridge University Press 02.04.2020
Subjects:
Age
Albumin
Albumins
Blood pressure
Cardiac arrhythmia
Cardiovascular disease
Chronic obstructive pulmonary disease
Coronary vessels
Demographics
Ethnicity
Gender
Health risk assessment
Heart failure
Heart rate
Hemoglobin
Infections
Intensive care
Kidney diseases
Laboratories
Liver diseases
Mortality
Multivariate analysis
Original Paper
Physiology
Pneumonia
Quartiles
Sepsis
Septic shock
Statistical models
Structured Query Language-SQL
Studies
Subgroups
Vital signs
mortality
septic shock
severe sepsis
Intensive care unit
neutrophil percentage-to-albumin ratio
ISSN:0950-2688, 1469-4409, 1469-4409
Online Access:Get full text
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Summary:There has been no study exploring the prognostic values of neutrophil percentage-to-albumin ratio (NPAR). We hypothesised that NPAR is a novel marker of inflammation and is associated with all-cause mortality in patients with severe sepsis or septic shock. Patient data were extracted from the MIMIC-III V1.4 database. Only the data for the first intensive care unit (ICU) admission of each patient were used and baseline data were extracted within 24 h after ICU admission. The clinical endpoints were 30-, 90- and 365-day all-cause mortality in critically ill patients with severe sepsis or septic shock. Cox proportional hazards models and subgroup analyses were used to determine the relationship between NPAR and these clinical endpoints. A total of 2166 patients were eligible for this analysis. In multivariate analysis, after adjustments for age, ethnicity and gender, higher NPAR was associated with increased risk of 30-, 90- and 365-day all-cause mortality in critically ill patients with severe sepsis or septic shock. Furthermore, after adjusting for more confounding factors, higher NPAR remained a significant predictor of all-cause mortality (tertile 3 vs . tertile 1: HR, 95% CI: 1.29, 1.04–1.61; 1.41, 1.16–1.72; 1.44, 1.21–1.71). A similar trend was observed in NPAR levels stratified by quartiles. Higher NPAR was associated with increased risk of all-cause mortality in critically ill patients with severe sepsis or septic shock.
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ISSN:0950-2688
1469-4409
1469-4409
DOI:10.1017/S0950268820000771