Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions

[Display omitted] •Sensitive and specific 19F NMR for quantification of the fluorinated vehicle.•Simultaneous analysis of the vehicle component and active drug.•To set their penetration behaviour in relation, their relative slopes were calculated.•Microemulsion systems exerted a ‘push’ on drug skin...

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Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 88; no. 1; pp. 34 - 39
Main Authors:	Mahrhauser, Denise, Hoppel, Magdalena, Schöll, Judith, Binder, Lisa, Kählig, Hanspeter, Valenta, Claudia
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2014
Subjects:	19F NMR Animals ATR-FTIR Chromatography, High Pressure Liquid Diclofenac - chemistry Drug Delivery Systems Ear, External - drug effects Emulsions Fluorine Fluorosurfactant Lipids - chemistry Magnetic Resonance Spectroscopy Microemulsion Oleic Acid - chemistry Rheology Simultaneous analysis Skin - drug effects Skin Absorption Sodium - chemistry Spectroscopy, Fourier Transform Infrared Surface-Active Agents - administration & dosage Surface-Active Agents - chemistry Swine Vehicle penetration SC Fluorosurfactant ATR-FTIR Vehicle penetration ME SIN HEX Microemulsion FS Simultaneous analysis 19F NMR DS F NMR
ISSN:	0939-6411, 1873-3441, 1873-3441
Online Access:	Get full text
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