Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluoresce...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1780; no. 4; pp. 673 - 679
Main Authors:	Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., Priyadarsini, K.I.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2008
Subjects:	Animals Biological Transport Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cellular uptake Curcuma - chemistry Curcumin Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fluorescence Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Mice Microscopy, Confocal NIH 3T3 Cells Nuclear localization Spectrometry, Fluorescence Time Factors Tumor cell Fluorescence Cytotoxicity Cellular uptake Curcumin Nuclear localization Tumor cell
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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