Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluoresce...

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Vydáno v:	Biochimica et biophysica acta Ročník 1780; číslo 4; s. 673 - 679
Hlavní autoři:	Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., Priyadarsini, K.I.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.04.2008
Témata:	Animals Biological Transport Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cellular uptake Curcuma - chemistry Curcumin Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fluorescence Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Mice Microscopy, Confocal NIH 3T3 Cells Nuclear localization Spectrometry, Fluorescence Time Factors Tumor cell Fluorescence Cytotoxicity Cellular uptake Curcumin Nuclear localization Tumor cell
ISSN:	0304-4165, 0006-3002, 1872-8006
On-line přístup:	Získat plný text
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Abstract	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.
AbstractList	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake. Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake. Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.
Author	Pandey, R. Mishra, B. Barik, A. Rathinasamy, K. Priyadarsini, K.I. Kunwar, A.
Author_xml	– sequence: 1 givenname: A. surname: Kunwar fullname: Kunwar, A. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 2 givenname: A. surname: Barik fullname: Barik, A. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 3 givenname: B. surname: Mishra fullname: Mishra, B. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 4 givenname: K. surname: Rathinasamy fullname: Rathinasamy, K. organization: School of Biosciences and Bioengineering, IIT-Bombay, Mumbai, 400 076, India – sequence: 5 givenname: R. surname: Pandey fullname: Pandey, R. organization: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 6 givenname: K.I. surname: Priyadarsini fullname: Priyadarsini, K.I. email: kindira@barc.gov.in organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18178166$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1146/annurev.physiol.66.032902.131835 10.1016/S0955-0674(99)00021-6 10.1016/j.saa.2004.10.007 10.1158/0008-5472.CAN-03-3829 10.2174/187152006776930918 10.1111/j.1751-1097.1994.tb05037.x 10.1177/002215549704500107 10.1016/j.molliq.2003.12.013 10.1562/0031-8655(2003)077<0597:PSOBOC>2.0.CO;2 10.1002/(SICI)1098-2299(200001)49:1<34::AID-DDR6>3.0.CO;2-W 10.1016/0022-1759(83)90303-4 10.1562/0031-8655(2000)072<0625:EOSOTE>2.0.CO;2 10.1016/j.cell.2007.08.024 10.1074/jbc.273.5.3003 10.1146/annurev.bi.43.070174.004105 10.1016/j.cplett.2007.01.006 10.1271/bbb1961.54.2961 10.1196/annals.1352.010 10.1021/jf9900837 10.1016/j.bbagen.2006.06.012 10.1002/gepi.10226 10.1016/S0891-5849(97)00026-9 10.1146/annurev.bioeng.8.061505.095753 10.1016/S1567-5769(03)00140-1 10.1016/j.ejca.2005.05.009 10.1002/bies.1132
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References	Singer (bib16) 1974; 43 Glunde, Chunfa, Bhujwalla (bib32) 2004; 64 Aggarwal, Sundaram, Malani, Ichikawa (bib1) 2007 Kunwar, Barik, Pandey, Priyadarsini (bib9) 2006; 1760 Singh, Khar (bib5) 2006; 6 Mosmann (bib14) 1983; 65 Singh (bib7) 2007; 130 Began, Sudharshan, Sankar, Appu Rao (bib21) 1999; 47 Sharma, Gescher, Steward (bib4) 2005; 41 Singer (bib17) 2004; 66 Khopde, Priyadarsini, Palit, Mukherjee (bib20) 2000; 72 Troyanovsky (bib26) 1999; 11 Shishodia, Sethi, Aggarwal (bib6) 2005; 1056 Suzuki (bib28) 2006; 51 Wang, Yang, Wu, Liu (bib24) 2005; 61 Coda, Salcini, Confalonieri, Pelicci, Sorkina, Sorkin, Pelicci, Di Fiore (bib13) 1998; 273 Suzui, Fujikura, Higashiyama, Takata (bib15) 1997; 45 Chignell, Bilski, Reszka, Motten, Sik, Dhal (bib18) 1994; 59 Aggarwal, Kumar, Bharti (bib3) 2003; 23 Barik, Priyadarsini, Mohan (bib23) 2003; 77 Barik, Mishra, Kunwar, Priyadarsini (bib25) 2007; 436 Földes-Papp, Demel, Tilz (bib12) 2003; 3 Paweletz, Gillespie, Ornstein, Simone, Brown, Cole, Wang, Huang, Hu Nan, Yip, Rich, Kohn, Linehan, Weber, Taylor, Emmert-Buck, Liotta, Petricoin (bib31) 2000; 49 Chattopadhyay, Biswas, Bandyopadhyay, Banerjee (bib2) 2004; 87 Priyadarsini (bib8) 1997; 23 Trivedi, Kitabatake, Doi (bib11) 1990; 54 Iwunze (bib22) 2004; 111 Savagner (bib29) 2001; 23 Leckband Prakasam (bib27) 2006; 8 Bong (bib19) 2000; 21 Sellers, Yates (bib30) 2003; 24 Kunwar (10.1016/j.bbagen.2007.11.016_bib9) 2006; 1760 Bong (10.1016/j.bbagen.2007.11.016_bib19) 2000; 21 Singh (10.1016/j.bbagen.2007.11.016_bib5) 2006; 6 Singer (10.1016/j.bbagen.2007.11.016_bib16) 1974; 43 Sellers (10.1016/j.bbagen.2007.11.016_bib30) 2003; 24 Aggarwal (10.1016/j.bbagen.2007.11.016_bib3) 2003; 23 10.1016/j.bbagen.2007.11.016_bib10 Singer (10.1016/j.bbagen.2007.11.016_bib17) 2004; 66 Iwunze (10.1016/j.bbagen.2007.11.016_bib22) 2004; 111 Suzui (10.1016/j.bbagen.2007.11.016_bib15) 1997; 45 Aggarwal (10.1016/j.bbagen.2007.11.016_bib1) 2007 Singh (10.1016/j.bbagen.2007.11.016_bib7) 2007; 130 Chignell (10.1016/j.bbagen.2007.11.016_bib18) 1994; 59 Glunde (10.1016/j.bbagen.2007.11.016_bib32) 2004; 64 Mosmann (10.1016/j.bbagen.2007.11.016_bib14) 1983; 65 Paweletz (10.1016/j.bbagen.2007.11.016_bib31) 2000; 49 Barik (10.1016/j.bbagen.2007.11.016_bib23) 2003; 77 Sharma (10.1016/j.bbagen.2007.11.016_bib4) 2005; 41 Trivedi (10.1016/j.bbagen.2007.11.016_bib11) 1990; 54 Shishodia (10.1016/j.bbagen.2007.11.016_bib6) 2005; 1056 Began (10.1016/j.bbagen.2007.11.016_bib21) 1999; 47 Barik (10.1016/j.bbagen.2007.11.016_bib25) 2007; 436 Suzuki (10.1016/j.bbagen.2007.11.016_bib28) 2006; 51 Földes-Papp (10.1016/j.bbagen.2007.11.016_bib12) 2003; 3 Savagner (10.1016/j.bbagen.2007.11.016_bib29) 2001; 23 Priyadarsini (10.1016/j.bbagen.2007.11.016_bib8) 1997; 23 Leckband Prakasam (10.1016/j.bbagen.2007.11.016_bib27) 2006; 8 Wang (10.1016/j.bbagen.2007.11.016_bib24) 2005; 61 Coda (10.1016/j.bbagen.2007.11.016_bib13) 1998; 273 Troyanovsky (10.1016/j.bbagen.2007.11.016_bib26) 1999; 11 Khopde (10.1016/j.bbagen.2007.11.016_bib20) 2000; 72 Chattopadhyay (10.1016/j.bbagen.2007.11.016_bib2) 2004; 87
References_xml	– volume: 23 start-page: 363 year: 2003 end-page: 398 ident: bib3 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 66 start-page: 1 year: 2004 end-page: 27 ident: bib17 article-title: Some early history of membrane molecular biology publication-title: Ann. Rev. Physiology – volume: 59 start-page: 295 year: 1994 end-page: 302 ident: bib18 article-title: Spectral and photochemical properties of curcumin publication-title: Photochem. Photobiol. – volume: 43 start-page: 805 year: 1974 end-page: 833 ident: bib16 article-title: The molecular organization of membranes publication-title: Ann. Rev. Biochem. – start-page: 1 year: 2007 end-page: 76 ident: bib1 article-title: Curcumin: the Indian solid gold publication-title: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease – volume: 21 start-page: 81 year: 2000 end-page: 86 ident: bib19 article-title: Spectral and photophysical behaviours of curcumin and curcuminoids publication-title: Bull. Korean Chem. Soc. – volume: 77 start-page: 597 year: 2003 end-page: 603 ident: bib23 article-title: Photophysical studies on binding of curcumin to bovine serum albumin publication-title: Photochem. Photobiol. – volume: 1056 start-page: 206 year: 2005 end-page: 217 ident: bib6 article-title: Curcumin: getting back to the roots publication-title: Ann. N.Y. Acad. Sci. – volume: 6 start-page: 933 year: 2006 end-page: 946 ident: bib5 article-title: Biological effects of curcumin and its role in cancer chemoprevention and therapy publication-title: Anticancer Agents Med. Chem. – volume: 47 start-page: 4992 year: 1999 end-page: 4997 ident: bib21 article-title: Interaction of curcumin with phosphatidylcholine: a spectrofluorometric study publication-title: J. Agric. Food Chem. – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: bib14 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods – volume: 8 start-page: 259 year: 2006 end-page: 287 ident: bib27 article-title: Mechanism and dynamics of cadherin adhesion publication-title: Ann. Rev. Biomed. Eng. – volume: 1760 start-page: 1513 year: 2006 end-page: 1520 ident: bib9 article-title: Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence study publication-title: Biochim. Biophys. Acta – volume: 41 start-page: 1955 year: 2005 end-page: 1968 ident: bib4 article-title: Curcumin: the story so far publication-title: Eur. J. Cancer – volume: 61 start-page: 2650 year: 2005 end-page: 2656 ident: bib24 article-title: Study of the interaction of proteins with curcumin and SDS and its analytical application publication-title: Spectrochim. Acta A Mol. Biomol. Spectros. – volume: 273 start-page: 3003 year: 1998 end-page: 3012 ident: bib13 article-title: Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization publication-title: J. Biol. Chem. – volume: 436 start-page: 239 year: 2007 end-page: 243 ident: bib25 article-title: Interaction of curcumin with human serum albumin: thermodynamic properties, fluorescence energy transfer and denaturation effects publication-title: Chem. Phys. Lett. – volume: 51 start-page: 629 year: 2006 end-page: 635 ident: bib28 article-title: Structure and function of cadherins publication-title: Tanpakushitsu Kakusan Koso – volume: 3 start-page: 1715 year: 2003 end-page: 1729 ident: bib12 article-title: Laser scanning confocal fluorescence microscopy: an overview publication-title: Int. Immunopharmacology – volume: 130 start-page: 765 year: 2007 end-page: 768 ident: bib7 article-title: From exotic spice to modern drug publication-title: Cell – volume: 64 start-page: 4270 year: 2004 end-page: 4276 ident: bib32 article-title: Molecular causes of the aberrant choline phospholipid metabolism in breast cancer publication-title: Cancer Research – volume: 87 start-page: 44 year: 2004 end-page: 53 ident: bib2 article-title: Turmeric and curcumin: biological actions and medicinal applications publication-title: Curr. Sci. – volume: 72 start-page: 625 year: 2000 end-page: 631 ident: bib20 article-title: Effect of solvent on the excited state photophysical properties of curcumin publication-title: Photochem. Photobiol. – volume: 23 start-page: 912 year: 2001 end-page: 923 ident: bib29 article-title: Leaving the neighborhood: molecular mechanisms involved during epithelial–mesenchymal transition publication-title: BioEssays – volume: 45 start-page: 49 year: 1997 end-page: 53 ident: bib15 article-title: DNA staining for fluorescence and laser confocal microscopy publication-title: J. Histochem. Cytochem. – volume: 11 start-page: 561 year: 1999 end-page: 566 ident: bib26 article-title: Mechanism of cell–cell adhesion complex assembly publication-title: Curr. Opin. Cell Biol. – volume: 54 start-page: 2961 year: 1990 end-page: 2966 ident: bib11 article-title: Toxicity of dimethyl sulphoxide as a solvent in bioassay system with HeLa cells evaluated colorimetrically with 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide publication-title: Agric. Biol. Chem. – volume: 111 start-page: 161 year: 2004 end-page: 165 ident: bib22 article-title: Binding and distribution characteristics of curcumin solubilised in CTAB micelle publication-title: J. Mol. Liquids – volume: 23 start-page: 838 year: 1997 end-page: 846 ident: bib8 article-title: Free radical reactions of curcumin in membrane model publication-title: Free Radic. Biol. Med. – volume: 49 start-page: 34 year: 2000 end-page: 42 ident: bib31 article-title: Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip publication-title: Drug Development Research – volume: 24 start-page: 83 year: 2003 end-page: 98 ident: bib30 article-title: Review of proteomics with applications to genetic epidemiology publication-title: Genetic Epidemiology – volume: 66 start-page: 1 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib17 article-title: Some early history of membrane molecular biology publication-title: Ann. Rev. Physiology doi: 10.1146/annurev.physiol.66.032902.131835 – volume: 11 start-page: 561 year: 1999 ident: 10.1016/j.bbagen.2007.11.016_bib26 article-title: Mechanism of cell–cell adhesion complex assembly publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(99)00021-6 – volume: 23 start-page: 363 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib3 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 61 start-page: 2650 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib24 article-title: Study of the interaction of proteins with curcumin and SDS and its analytical application publication-title: Spectrochim. Acta A Mol. Biomol. Spectros. doi: 10.1016/j.saa.2004.10.007 – volume: 21 start-page: 81 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib19 article-title: Spectral and photophysical behaviours of curcumin and curcuminoids publication-title: Bull. Korean Chem. Soc. – volume: 64 start-page: 4270 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib32 article-title: Molecular causes of the aberrant choline phospholipid metabolism in breast cancer publication-title: Cancer Research doi: 10.1158/0008-5472.CAN-03-3829 – volume: 6 start-page: 933 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib5 article-title: Biological effects of curcumin and its role in cancer chemoprevention and therapy publication-title: Anticancer Agents Med. Chem. doi: 10.2174/187152006776930918 – volume: 59 start-page: 295 year: 1994 ident: 10.1016/j.bbagen.2007.11.016_bib18 article-title: Spectral and photochemical properties of curcumin publication-title: Photochem. Photobiol. doi: 10.1111/j.1751-1097.1994.tb05037.x – volume: 45 start-page: 49 year: 1997 ident: 10.1016/j.bbagen.2007.11.016_bib15 article-title: DNA staining for fluorescence and laser confocal microscopy publication-title: J. Histochem. Cytochem. doi: 10.1177/002215549704500107 – volume: 111 start-page: 161 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib22 article-title: Binding and distribution characteristics of curcumin solubilised in CTAB micelle publication-title: J. Mol. Liquids doi: 10.1016/j.molliq.2003.12.013 – volume: 77 start-page: 597 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib23 article-title: Photophysical studies on binding of curcumin to bovine serum albumin publication-title: Photochem. Photobiol. doi: 10.1562/0031-8655(2003)077<0597:PSOBOC>2.0.CO;2 – ident: 10.1016/j.bbagen.2007.11.016_bib10 – volume: 49 start-page: 34 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib31 article-title: Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip publication-title: Drug Development Research doi: 10.1002/(SICI)1098-2299(200001)49:1<34::AID-DDR6>3.0.CO;2-W – volume: 65 start-page: 55 year: 1983 ident: 10.1016/j.bbagen.2007.11.016_bib14 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(83)90303-4 – volume: 72 start-page: 625 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib20 article-title: Effect of solvent on the excited state photophysical properties of curcumin publication-title: Photochem. Photobiol. doi: 10.1562/0031-8655(2000)072<0625:EOSOTE>2.0.CO;2 – volume: 130 start-page: 765 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib7 article-title: From exotic spice to modern drug publication-title: Cell doi: 10.1016/j.cell.2007.08.024 – volume: 273 start-page: 3003 year: 1998 ident: 10.1016/j.bbagen.2007.11.016_bib13 article-title: Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.5.3003 – volume: 43 start-page: 805 year: 1974 ident: 10.1016/j.bbagen.2007.11.016_bib16 article-title: The molecular organization of membranes publication-title: Ann. Rev. Biochem. doi: 10.1146/annurev.bi.43.070174.004105 – volume: 436 start-page: 239 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib25 article-title: Interaction of curcumin with human serum albumin: thermodynamic properties, fluorescence energy transfer and denaturation effects publication-title: Chem. Phys. Lett. doi: 10.1016/j.cplett.2007.01.006 – volume: 54 start-page: 2961 year: 1990 ident: 10.1016/j.bbagen.2007.11.016_bib11 article-title: Toxicity of dimethyl sulphoxide as a solvent in bioassay system with HeLa cells evaluated colorimetrically with 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide publication-title: Agric. Biol. Chem. doi: 10.1271/bbb1961.54.2961 – volume: 1056 start-page: 206 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib6 article-title: Curcumin: getting back to the roots publication-title: Ann. N.Y. Acad. Sci. doi: 10.1196/annals.1352.010 – volume: 47 start-page: 4992 year: 1999 ident: 10.1016/j.bbagen.2007.11.016_bib21 article-title: Interaction of curcumin with phosphatidylcholine: a spectrofluorometric study publication-title: J. Agric. Food Chem. doi: 10.1021/jf9900837 – volume: 87 start-page: 44 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib2 article-title: Turmeric and curcumin: biological actions and medicinal applications publication-title: Curr. Sci. – volume: 1760 start-page: 1513 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib9 article-title: Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence study publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2006.06.012 – volume: 24 start-page: 83 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib30 article-title: Review of proteomics with applications to genetic epidemiology publication-title: Genetic Epidemiology doi: 10.1002/gepi.10226 – volume: 23 start-page: 838 year: 1997 ident: 10.1016/j.bbagen.2007.11.016_bib8 article-title: Free radical reactions of curcumin in membrane model publication-title: Free Radic. Biol. Med. doi: 10.1016/S0891-5849(97)00026-9 – volume: 8 start-page: 259 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib27 article-title: Mechanism and dynamics of cadherin adhesion publication-title: Ann. Rev. Biomed. Eng. doi: 10.1146/annurev.bioeng.8.061505.095753 – volume: 3 start-page: 1715 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib12 article-title: Laser scanning confocal fluorescence microscopy: an overview publication-title: Int. Immunopharmacology doi: 10.1016/S1567-5769(03)00140-1 – start-page: 1 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib1 article-title: Curcumin: the Indian solid gold – volume: 41 start-page: 1955 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib4 article-title: Curcumin: the story so far publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2005.05.009 – volume: 51 start-page: 629 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib28 article-title: Structure and function of cadherins publication-title: Tanpakushitsu Kakusan Koso – volume: 23 start-page: 912 year: 2001 ident: 10.1016/j.bbagen.2007.11.016_bib29 article-title: Leaving the neighborhood: molecular mechanisms involved during epithelial–mesenchymal transition publication-title: BioEssays doi: 10.1002/bies.1132
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Snippet	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was... Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was...
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SubjectTerms	Animals Biological Transport Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cellular uptake Curcuma - chemistry Curcumin Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fluorescence Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Mice Microscopy, Confocal NIH 3T3 Cells Nuclear localization Spectrometry, Fluorescence Time Factors Tumor cell
Title	Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells
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