Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluoresce...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1780; no. 4; pp. 673 - 679
Main Authors:	Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., Priyadarsini, K.I.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2008
Subjects:	Animals Biological Transport Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cellular uptake Curcuma - chemistry Curcumin Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fluorescence Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Mice Microscopy, Confocal NIH 3T3 Cells Nuclear localization Spectrometry, Fluorescence Time Factors Tumor cell Fluorescence Cytotoxicity Cellular uptake Curcumin Nuclear localization Tumor cell
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.
AbstractList	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake. Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake. Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7. Both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. A linear dependency on the uptake was observed with treatment concentration of curcumin. Using laser confocal microscopy, intracellular localization of curcumin was monitored and the results indicated that curcumin is located both in the cell membrane and the nucleus. Sub-cellular fractionation of curcumin-loaded MCF7 cells supported the differential distribution of curcumin in membrane, cytoplasm and nuclear compartments of cell with maximum localization in the membrane. Cytotoxicity studies in different cell lines indicated that the toxicity of curcumin increased with increasing uptake.
Author	Pandey, R. Mishra, B. Barik, A. Rathinasamy, K. Priyadarsini, K.I. Kunwar, A.
Author_xml	– sequence: 1 givenname: A. surname: Kunwar fullname: Kunwar, A. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 2 givenname: A. surname: Barik fullname: Barik, A. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 3 givenname: B. surname: Mishra fullname: Mishra, B. organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 4 givenname: K. surname: Rathinasamy fullname: Rathinasamy, K. organization: School of Biosciences and Bioengineering, IIT-Bombay, Mumbai, 400 076, India – sequence: 5 givenname: R. surname: Pandey fullname: Pandey, R. organization: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India – sequence: 6 givenname: K.I. surname: Priyadarsini fullname: Priyadarsini, K.I. email: kindira@barc.gov.in organization: Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18178166$$D View this record in MEDLINE/PubMed
BookMark	eNqFkF1LHDEUhkOx1NX2H0iZq14502Qmk8l6URCxrSCIoNfhTD4k25lkzYe4_nqzu5ZCL9oQCJw878vhOUIHzjuN0AnBDcGEfV014wgP2jUtxkNDSFOG79CC8KGtOcbsAC1wh2lNCesP0VGMK1xOv-w_oEPCycAJYwsEtxlcsgmSfdKV1NOUJwhVXif4pU-ryUuY7Ev59a4Cpyq5ST75Zytt2lTeVDIHmWfrqnKdDzNMOyzl2YddXfyI3huYov709h6j---Xdxc_6-ubH1cX59e1pC1LtWQj5YapjnKgoyFmWEpDVNcyptTYD8uREOByoGNHB8K6VnJmTEvVkmsDHLpj9GXfuw7-MeuYxGzjdgNw2ucoBkwpbtu-gJ_fwDzOWol1sDOEjfgtpQB0D8jgYwza_EGw2LoXK7F3L7buBSGiDEvs7K-Y3Hn1LgWw0__C3_ZhXRQ9WR1ElFY7qZUNWiahvP13wSsMtqNY
CitedBy_id	crossref_primary_10_1002_fsn3_1930 crossref_primary_10_1016_j_ijpharm_2021_120828 crossref_primary_10_1016_j_chemosphere_2020_127756 crossref_primary_10_1007_s10103_013_1357_7 crossref_primary_10_3109_10715762_2011_571681 crossref_primary_10_1134_S0030400X20060235 crossref_primary_10_1002_adtp_202000010 crossref_primary_10_1007_s10544_016_0062_2 crossref_primary_10_1186_1471_2407_14_724 crossref_primary_10_1016_j_colsurfb_2013_03_059 crossref_primary_10_1002_ptr_6482 crossref_primary_10_1007_s11095_018_2442_1 crossref_primary_10_5662_wjm_v13_i3_29 crossref_primary_10_1136_bcr_2018_224611 crossref_primary_10_1016_j_biomaterials_2010_04_062 crossref_primary_10_1517_17425247_2014_917076 crossref_primary_10_1016_j_freeradbiomed_2015_04_017 crossref_primary_10_1016_j_ijpharm_2010_07_021 crossref_primary_10_3109_14756366_2013_837901 crossref_primary_10_3390_ijms22115760 crossref_primary_10_3892_ijo_2020_5065 crossref_primary_10_1039_c1pp05120b crossref_primary_10_1074_jbc_RA117_000123 crossref_primary_10_1016_j_matdes_2019_108313 crossref_primary_10_3390_pharmaceutics14122688 crossref_primary_10_3889_oamjms_2021_5941 crossref_primary_10_1016_j_bcp_2010_06_022 crossref_primary_10_1080_10717544_2020_1785581 crossref_primary_10_1016_S2225_4110_16_30081_5 crossref_primary_10_3390_pharmaceutics15020639 crossref_primary_10_1016_j_nano_2014_09_004 crossref_primary_10_1055_a_2157_8913 crossref_primary_10_1016_j_biomaterials_2010_06_007 crossref_primary_10_1016_j_jddst_2022_103352 crossref_primary_10_1007_s10495_008_0224_7 crossref_primary_10_1002_jbt_22616 crossref_primary_10_1016_j_intimp_2020_106991 crossref_primary_10_1080_01635581_2019_1604978 crossref_primary_10_1186_s13075_016_1025_y crossref_primary_10_1088_2043_6262_6_1_015009 crossref_primary_10_1016_j_tiv_2025_106144 crossref_primary_10_1007_s43440_022_00383_y crossref_primary_10_1155_2013_239354 crossref_primary_10_1186_1476_4598_12_37 crossref_primary_10_1016_j_ijbiomac_2017_11_115 crossref_primary_10_3390_biom11050674 crossref_primary_10_1186_s12951_018_0428_0 crossref_primary_10_1016_j_carbpol_2010_08_008 crossref_primary_10_1038_cddiscovery_2015_17 crossref_primary_10_3390_molecules200814293 crossref_primary_10_1002_adtp_202200293 crossref_primary_10_1007_s00204_011_0786_y crossref_primary_10_1007_s11033_012_1851_1 crossref_primary_10_1016_j_colsurfb_2013_06_032 crossref_primary_10_1016_j_ijbiomac_2024_132210 crossref_primary_10_1016_j_procbio_2021_12_007 crossref_primary_10_1016_j_ijpharm_2013_12_007 crossref_primary_10_3390_pharmaceutics13091331 crossref_primary_10_3390_molecules25143205 crossref_primary_10_1016_j_jnutbio_2023_109283 crossref_primary_10_1016_j_eurpolymj_2019_01_058 crossref_primary_10_3389_fphar_2022_889816 crossref_primary_10_1016_j_actbio_2022_06_046 crossref_primary_10_3390_nu11122982 crossref_primary_10_1016_j_bcp_2009_06_105 crossref_primary_10_1016_j_ctarc_2025_100981 crossref_primary_10_1016_j_jphotochemrev_2009_05_001 crossref_primary_10_1080_01480545_2021_2015242 crossref_primary_10_1002_jbio_201800018 crossref_primary_10_1080_09205063_2018_1541500 crossref_primary_10_1016_j_foodres_2019_02_036 crossref_primary_10_1088_2053_1583_acc413 crossref_primary_10_3390_molecules24224067 crossref_primary_10_1002_jcb_24466 crossref_primary_10_3390_pharmaceutics13091460 crossref_primary_10_1016_j_jddst_2019_01_013 crossref_primary_10_1002_jps_22716 crossref_primary_10_1111_bph_12513 crossref_primary_10_2903_j_efsa_2010_1679 crossref_primary_10_1016_j_ijpharm_2012_07_062 crossref_primary_10_3390_medsci5040038 crossref_primary_10_1016_j_procbio_2014_12_029 crossref_primary_10_1016_j_chemphyslip_2023_105292 crossref_primary_10_1038_emm_2017_199 crossref_primary_10_1080_09205063_2014_941261 crossref_primary_10_1002_biof_1828 crossref_primary_10_1007_s10103_020_03150_8 crossref_primary_10_1016_j_saa_2016_04_051 crossref_primary_10_3389_fonc_2021_672490 crossref_primary_10_3109_02713683_2014_987870 crossref_primary_10_3390_biomedicines9111562 crossref_primary_10_1016_j_ijbiomac_2016_08_050 crossref_primary_10_1016_j_neuint_2015_10_011 crossref_primary_10_1007_s11356_021_12809_w crossref_primary_10_1016_j_phymed_2019_152902 crossref_primary_10_1007_s00044_015_1457_y crossref_primary_10_1016_j_ijpharm_2019_118791 crossref_primary_10_3390_metabo12070639 crossref_primary_10_1007_s13105_015_0405_0 crossref_primary_10_1016_j_ijbiomac_2024_135141 crossref_primary_10_1039_c2pp25249j crossref_primary_10_1136_lupus_2015_000114 crossref_primary_10_1088_0957_4484_26_11_115101 crossref_primary_10_1002_ptr_6663 crossref_primary_10_2174_0118741045349977241125104444 crossref_primary_10_1155_2018_4057959 crossref_primary_10_1371_journal_pone_0202677 crossref_primary_10_3390_nano8110907 crossref_primary_10_1016_j_biopha_2018_05_127 crossref_primary_10_1016_j_ejps_2021_105756 crossref_primary_10_1007_s12013_012_9443_1 crossref_primary_10_1016_j_jinorgbio_2017_05_002 crossref_primary_10_1111_j_1747_0285_2011_01083_x crossref_primary_10_1371_journal_pone_0225660 crossref_primary_10_1002_open_201800287 crossref_primary_10_3390_nu15194245 crossref_primary_10_1080_10286020_2024_2420619 crossref_primary_10_1002_jcp_27370 crossref_primary_10_1111_1750_3841_13800 crossref_primary_10_1163_092050611X581534 crossref_primary_10_1016_j_ejmech_2019_07_015 crossref_primary_10_1002_jbio_201000119 crossref_primary_10_3390_nano12203619 crossref_primary_10_1007_s43630_024_00571_0 crossref_primary_10_3390_molecules23123351 crossref_primary_10_1016_j_ejpb_2020_10_003 crossref_primary_10_1016_j_nano_2016_11_004 crossref_primary_10_1016_j_prostaglandins_2009_06_005 crossref_primary_10_1016_j_colsurfa_2019_01_043 crossref_primary_10_1371_journal_pone_0132845 crossref_primary_10_1016_j_tet_2025_134607 crossref_primary_10_1155_2017_9656719 crossref_primary_10_1039_c9pp00375d crossref_primary_10_1016_j_carbpol_2013_01_014 crossref_primary_10_3390_ijms23179569 crossref_primary_10_1016_j_jconrel_2022_06_023 crossref_primary_10_3390_ijms251910692 crossref_primary_10_3390_molecules14125328 crossref_primary_10_3390_molecules30030701 crossref_primary_10_2147_IJN_S258060 crossref_primary_10_1021_acsami_4c22606 crossref_primary_10_3390_md18040217 crossref_primary_10_1016_j_colsurfb_2017_01_023 crossref_primary_10_1016_j_mtcomm_2025_112220 crossref_primary_10_1038_s41581_024_00819_z crossref_primary_10_3892_ol_2013_1341 crossref_primary_10_1016_j_ultsonch_2016_04_012 crossref_primary_10_1016_j_fct_2012_06_012 crossref_primary_10_1016_j_tips_2008_11_002 crossref_primary_10_3390_ijms25084380 crossref_primary_10_1038_bonekey_2016_20 crossref_primary_10_1016_S2222_1808_15_61057_X crossref_primary_10_1002_anie_202417024 crossref_primary_10_1016_j_tiv_2012_11_003 crossref_primary_10_1208_s12248_009_9128_x crossref_primary_10_1038_s41598_021_98243_x crossref_primary_10_1080_10715762_2018_1455002 crossref_primary_10_1016_j_cplett_2021_138616 crossref_primary_10_2217_nnm_10_9 crossref_primary_10_1039_D0SC02097D crossref_primary_10_3390_ma9070520 crossref_primary_10_3390_nu13020332 crossref_primary_10_3390_pharmaceutics16020205 crossref_primary_10_1016_j_ijbiomac_2017_10_170 crossref_primary_10_1002_ptr_6054 crossref_primary_10_1016_j_canlet_2015_11_021 crossref_primary_10_1088_2043_6254_1_1_015012 crossref_primary_10_1098_rsos_170865 crossref_primary_10_3390_polym14142904 crossref_primary_10_1016_j_molliq_2020_113591 crossref_primary_10_1007_s00249_015_1009_x crossref_primary_10_1186_1471_2407_11_149 crossref_primary_10_1002_ange_202417024 crossref_primary_10_2174_1381612829666230331084848 crossref_primary_10_3390_molecules28155719 crossref_primary_10_1016_j_colsurfb_2014_01_007 crossref_primary_10_1016_j_ejphar_2009_03_060 crossref_primary_10_3390_jox15050139 crossref_primary_10_1186_s12906_023_04096_4 crossref_primary_10_3390_ijerph192316193 crossref_primary_10_3390_ijms241511975 crossref_primary_10_1155_2022_8245614 crossref_primary_10_1016_j_ijbiomac_2011_04_008 crossref_primary_10_1371_journal_pone_0039568 crossref_primary_10_1016_j_ijbiomac_2016_12_090 crossref_primary_10_1016_j_tiv_2024_105917 crossref_primary_10_3390_ijms26104871 crossref_primary_10_1016_j_ijpharm_2024_124380 crossref_primary_10_1088_0957_4484_26_27_275101 crossref_primary_10_1208_s12248_016_0003_2 crossref_primary_10_1016_j_jcis_2011_04_006 crossref_primary_10_3390_nano8080588 crossref_primary_10_3109_02713680903528345 crossref_primary_10_3390_biology9050092 crossref_primary_10_1016_j_jnutbio_2014_06_009 crossref_primary_10_1016_j_ijbiomac_2024_136874 crossref_primary_10_1021_acsbiomaterials_9b01693 crossref_primary_10_1016_j_ijpharm_2019_03_055 crossref_primary_10_1186_s12917_017_1302_2 crossref_primary_10_3390_pharmaceutics15041275 crossref_primary_10_1016_j_saa_2013_06_066 crossref_primary_10_1007_s43630_024_00639_x crossref_primary_10_1016_j_ejmech_2015_11_049 crossref_primary_10_1111_cpr_12558 crossref_primary_10_3390_ph18030337 crossref_primary_10_1016_j_tiv_2021_105254 crossref_primary_10_1080_10520295_2017_1310925 crossref_primary_10_3390_md21040219 crossref_primary_10_1038_s41598_024_67713_3 crossref_primary_10_1016_j_mrfmmm_2014_05_006 crossref_primary_10_3390_pharmaceutics15071811 crossref_primary_10_1007_s43630_025_00735_6 crossref_primary_10_1007_s00280_018_3654_0 crossref_primary_10_1016_j_foodchem_2009_04_018 crossref_primary_10_1016_j_jorganchem_2009_10_041 crossref_primary_10_1007_s11095_014_1504_2 crossref_primary_10_1016_j_bioadv_2024_213886 crossref_primary_10_1186_1477_3155_11_37 crossref_primary_10_1016_j_aca_2011_04_028 crossref_primary_10_1093_jn_nxaa201 crossref_primary_10_3390_pharmaceutics14071486 crossref_primary_10_1007_s11101_014_9351_7 crossref_primary_10_1002_adhm_201901031 crossref_primary_10_1016_j_ejps_2019_05_006 crossref_primary_10_5487_TR_2013_29_1_035 crossref_primary_10_1007_s11101_013_9296_2 crossref_primary_10_3390_pharmaceutics11060282 crossref_primary_10_3390_pharmaceutics13010009 crossref_primary_10_1007_s12645_012_0031_2 crossref_primary_10_3390_jof8111218 crossref_primary_10_1038_jid_2011_96 crossref_primary_10_1080_07357907_2016_1247166 crossref_primary_10_1016_j_lfs_2020_118051 crossref_primary_10_1002_EXP_20230113 crossref_primary_10_1038_s41598_018_20179_6 crossref_primary_10_1016_j_nano_2011_07_011 crossref_primary_10_3892_ol_2019_10204 crossref_primary_10_1016_j_ejphar_2010_09_049 crossref_primary_10_1097_MPA_0000000000000411
Cites_doi	10.1146/annurev.physiol.66.032902.131835 10.1016/S0955-0674(99)00021-6 10.1016/j.saa.2004.10.007 10.1158/0008-5472.CAN-03-3829 10.2174/187152006776930918 10.1111/j.1751-1097.1994.tb05037.x 10.1177/002215549704500107 10.1016/j.molliq.2003.12.013 10.1562/0031-8655(2003)077<0597:PSOBOC>2.0.CO;2 10.1002/(SICI)1098-2299(200001)49:1<34::AID-DDR6>3.0.CO;2-W 10.1016/0022-1759(83)90303-4 10.1562/0031-8655(2000)072<0625:EOSOTE>2.0.CO;2 10.1016/j.cell.2007.08.024 10.1074/jbc.273.5.3003 10.1146/annurev.bi.43.070174.004105 10.1016/j.cplett.2007.01.006 10.1271/bbb1961.54.2961 10.1196/annals.1352.010 10.1021/jf9900837 10.1016/j.bbagen.2006.06.012 10.1002/gepi.10226 10.1016/S0891-5849(97)00026-9 10.1146/annurev.bioeng.8.061505.095753 10.1016/S1567-5769(03)00140-1 10.1016/j.ejca.2005.05.009 10.1002/bies.1132
ContentType	Journal Article
Copyright	2007 Elsevier B.V.
Copyright_xml	– notice: 2007 Elsevier B.V.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.bbagen.2007.11.016
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Biology
EISSN	1872-8006
EndPage	679
ExternalDocumentID	18178166 10_1016_j_bbagen_2007_11_016 S0304416507002796
Genre	Journal Article
GroupedDBID	--- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- 9DU AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD -~X .55 .GJ AAYJJ ABJNI AFFNX AI. CGR CUY CVF ECM EIF F5P H~9 K-O MVM NPM RIG TWZ UHS VH1 X7M Y6R YYP ZE2 ZGI ~KM 7X8
ID	FETCH-LOGICAL-c426t-c6b48f6d348a4bf1f79cf1d3266ddb579b11a8c74b3471632c86ff24d98efa8a3
ISICitedReferencesCount	319
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000256211400005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0304-4165 0006-3002
IngestDate	Thu Sep 04 19:33:04 EDT 2025 Thu Apr 03 06:56:05 EDT 2025 Tue Nov 18 22:01:44 EST 2025 Sat Nov 29 01:37:51 EST 2025 Fri Feb 23 02:32:36 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	4
Keywords	Fluorescence Cytotoxicity Cellular uptake Curcumin Nuclear localization Tumor cell
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c426t-c6b48f6d348a4bf1f79cf1d3266ddb579b11a8c74b3471632c86ff24d98efa8a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	18178166
PQID	70440225
PQPubID	23479
PageCount	7
ParticipantIDs	proquest_miscellaneous_70440225 pubmed_primary_18178166 crossref_primary_10_1016_j_bbagen_2007_11_016 crossref_citationtrail_10_1016_j_bbagen_2007_11_016 elsevier_sciencedirect_doi_10_1016_j_bbagen_2007_11_016
PublicationCentury	2000
PublicationDate	2008-04-01
PublicationDateYYYYMMDD	2008-04-01
PublicationDate_xml	– month: 04 year: 2008 text: 2008-04-01 day: 01
PublicationDecade	2000
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	Biochimica et biophysica acta
PublicationTitleAlternate	Biochim Biophys Acta
PublicationYear	2008
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Singer (bib16) 1974; 43 Glunde, Chunfa, Bhujwalla (bib32) 2004; 64 Aggarwal, Sundaram, Malani, Ichikawa (bib1) 2007 Kunwar, Barik, Pandey, Priyadarsini (bib9) 2006; 1760 Singh, Khar (bib5) 2006; 6 Mosmann (bib14) 1983; 65 Singh (bib7) 2007; 130 Began, Sudharshan, Sankar, Appu Rao (bib21) 1999; 47 Sharma, Gescher, Steward (bib4) 2005; 41 Singer (bib17) 2004; 66 Khopde, Priyadarsini, Palit, Mukherjee (bib20) 2000; 72 Troyanovsky (bib26) 1999; 11 Shishodia, Sethi, Aggarwal (bib6) 2005; 1056 Suzuki (bib28) 2006; 51 Wang, Yang, Wu, Liu (bib24) 2005; 61 Coda, Salcini, Confalonieri, Pelicci, Sorkina, Sorkin, Pelicci, Di Fiore (bib13) 1998; 273 Suzui, Fujikura, Higashiyama, Takata (bib15) 1997; 45 Chignell, Bilski, Reszka, Motten, Sik, Dhal (bib18) 1994; 59 Aggarwal, Kumar, Bharti (bib3) 2003; 23 Barik, Priyadarsini, Mohan (bib23) 2003; 77 Barik, Mishra, Kunwar, Priyadarsini (bib25) 2007; 436 Földes-Papp, Demel, Tilz (bib12) 2003; 3 Paweletz, Gillespie, Ornstein, Simone, Brown, Cole, Wang, Huang, Hu Nan, Yip, Rich, Kohn, Linehan, Weber, Taylor, Emmert-Buck, Liotta, Petricoin (bib31) 2000; 49 Chattopadhyay, Biswas, Bandyopadhyay, Banerjee (bib2) 2004; 87 Priyadarsini (bib8) 1997; 23 Trivedi, Kitabatake, Doi (bib11) 1990; 54 Iwunze (bib22) 2004; 111 Savagner (bib29) 2001; 23 Leckband Prakasam (bib27) 2006; 8 Bong (bib19) 2000; 21 Sellers, Yates (bib30) 2003; 24 Kunwar (10.1016/j.bbagen.2007.11.016_bib9) 2006; 1760 Bong (10.1016/j.bbagen.2007.11.016_bib19) 2000; 21 Singh (10.1016/j.bbagen.2007.11.016_bib5) 2006; 6 Singer (10.1016/j.bbagen.2007.11.016_bib16) 1974; 43 Sellers (10.1016/j.bbagen.2007.11.016_bib30) 2003; 24 Aggarwal (10.1016/j.bbagen.2007.11.016_bib3) 2003; 23 10.1016/j.bbagen.2007.11.016_bib10 Singer (10.1016/j.bbagen.2007.11.016_bib17) 2004; 66 Iwunze (10.1016/j.bbagen.2007.11.016_bib22) 2004; 111 Suzui (10.1016/j.bbagen.2007.11.016_bib15) 1997; 45 Aggarwal (10.1016/j.bbagen.2007.11.016_bib1) 2007 Singh (10.1016/j.bbagen.2007.11.016_bib7) 2007; 130 Chignell (10.1016/j.bbagen.2007.11.016_bib18) 1994; 59 Glunde (10.1016/j.bbagen.2007.11.016_bib32) 2004; 64 Mosmann (10.1016/j.bbagen.2007.11.016_bib14) 1983; 65 Paweletz (10.1016/j.bbagen.2007.11.016_bib31) 2000; 49 Barik (10.1016/j.bbagen.2007.11.016_bib23) 2003; 77 Sharma (10.1016/j.bbagen.2007.11.016_bib4) 2005; 41 Trivedi (10.1016/j.bbagen.2007.11.016_bib11) 1990; 54 Shishodia (10.1016/j.bbagen.2007.11.016_bib6) 2005; 1056 Began (10.1016/j.bbagen.2007.11.016_bib21) 1999; 47 Barik (10.1016/j.bbagen.2007.11.016_bib25) 2007; 436 Suzuki (10.1016/j.bbagen.2007.11.016_bib28) 2006; 51 Földes-Papp (10.1016/j.bbagen.2007.11.016_bib12) 2003; 3 Savagner (10.1016/j.bbagen.2007.11.016_bib29) 2001; 23 Priyadarsini (10.1016/j.bbagen.2007.11.016_bib8) 1997; 23 Leckband Prakasam (10.1016/j.bbagen.2007.11.016_bib27) 2006; 8 Wang (10.1016/j.bbagen.2007.11.016_bib24) 2005; 61 Coda (10.1016/j.bbagen.2007.11.016_bib13) 1998; 273 Troyanovsky (10.1016/j.bbagen.2007.11.016_bib26) 1999; 11 Khopde (10.1016/j.bbagen.2007.11.016_bib20) 2000; 72 Chattopadhyay (10.1016/j.bbagen.2007.11.016_bib2) 2004; 87
References_xml	– volume: 23 start-page: 363 year: 2003 end-page: 398 ident: bib3 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 66 start-page: 1 year: 2004 end-page: 27 ident: bib17 article-title: Some early history of membrane molecular biology publication-title: Ann. Rev. Physiology – volume: 59 start-page: 295 year: 1994 end-page: 302 ident: bib18 article-title: Spectral and photochemical properties of curcumin publication-title: Photochem. Photobiol. – volume: 43 start-page: 805 year: 1974 end-page: 833 ident: bib16 article-title: The molecular organization of membranes publication-title: Ann. Rev. Biochem. – start-page: 1 year: 2007 end-page: 76 ident: bib1 article-title: Curcumin: the Indian solid gold publication-title: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease – volume: 21 start-page: 81 year: 2000 end-page: 86 ident: bib19 article-title: Spectral and photophysical behaviours of curcumin and curcuminoids publication-title: Bull. Korean Chem. Soc. – volume: 77 start-page: 597 year: 2003 end-page: 603 ident: bib23 article-title: Photophysical studies on binding of curcumin to bovine serum albumin publication-title: Photochem. Photobiol. – volume: 1056 start-page: 206 year: 2005 end-page: 217 ident: bib6 article-title: Curcumin: getting back to the roots publication-title: Ann. N.Y. Acad. Sci. – volume: 6 start-page: 933 year: 2006 end-page: 946 ident: bib5 article-title: Biological effects of curcumin and its role in cancer chemoprevention and therapy publication-title: Anticancer Agents Med. Chem. – volume: 47 start-page: 4992 year: 1999 end-page: 4997 ident: bib21 article-title: Interaction of curcumin with phosphatidylcholine: a spectrofluorometric study publication-title: J. Agric. Food Chem. – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: bib14 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods – volume: 8 start-page: 259 year: 2006 end-page: 287 ident: bib27 article-title: Mechanism and dynamics of cadherin adhesion publication-title: Ann. Rev. Biomed. Eng. – volume: 1760 start-page: 1513 year: 2006 end-page: 1520 ident: bib9 article-title: Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence study publication-title: Biochim. Biophys. Acta – volume: 41 start-page: 1955 year: 2005 end-page: 1968 ident: bib4 article-title: Curcumin: the story so far publication-title: Eur. J. Cancer – volume: 61 start-page: 2650 year: 2005 end-page: 2656 ident: bib24 article-title: Study of the interaction of proteins with curcumin and SDS and its analytical application publication-title: Spectrochim. Acta A Mol. Biomol. Spectros. – volume: 273 start-page: 3003 year: 1998 end-page: 3012 ident: bib13 article-title: Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization publication-title: J. Biol. Chem. – volume: 436 start-page: 239 year: 2007 end-page: 243 ident: bib25 article-title: Interaction of curcumin with human serum albumin: thermodynamic properties, fluorescence energy transfer and denaturation effects publication-title: Chem. Phys. Lett. – volume: 51 start-page: 629 year: 2006 end-page: 635 ident: bib28 article-title: Structure and function of cadherins publication-title: Tanpakushitsu Kakusan Koso – volume: 3 start-page: 1715 year: 2003 end-page: 1729 ident: bib12 article-title: Laser scanning confocal fluorescence microscopy: an overview publication-title: Int. Immunopharmacology – volume: 130 start-page: 765 year: 2007 end-page: 768 ident: bib7 article-title: From exotic spice to modern drug publication-title: Cell – volume: 64 start-page: 4270 year: 2004 end-page: 4276 ident: bib32 article-title: Molecular causes of the aberrant choline phospholipid metabolism in breast cancer publication-title: Cancer Research – volume: 87 start-page: 44 year: 2004 end-page: 53 ident: bib2 article-title: Turmeric and curcumin: biological actions and medicinal applications publication-title: Curr. Sci. – volume: 72 start-page: 625 year: 2000 end-page: 631 ident: bib20 article-title: Effect of solvent on the excited state photophysical properties of curcumin publication-title: Photochem. Photobiol. – volume: 23 start-page: 912 year: 2001 end-page: 923 ident: bib29 article-title: Leaving the neighborhood: molecular mechanisms involved during epithelial–mesenchymal transition publication-title: BioEssays – volume: 45 start-page: 49 year: 1997 end-page: 53 ident: bib15 article-title: DNA staining for fluorescence and laser confocal microscopy publication-title: J. Histochem. Cytochem. – volume: 11 start-page: 561 year: 1999 end-page: 566 ident: bib26 article-title: Mechanism of cell–cell adhesion complex assembly publication-title: Curr. Opin. Cell Biol. – volume: 54 start-page: 2961 year: 1990 end-page: 2966 ident: bib11 article-title: Toxicity of dimethyl sulphoxide as a solvent in bioassay system with HeLa cells evaluated colorimetrically with 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide publication-title: Agric. Biol. Chem. – volume: 111 start-page: 161 year: 2004 end-page: 165 ident: bib22 article-title: Binding and distribution characteristics of curcumin solubilised in CTAB micelle publication-title: J. Mol. Liquids – volume: 23 start-page: 838 year: 1997 end-page: 846 ident: bib8 article-title: Free radical reactions of curcumin in membrane model publication-title: Free Radic. Biol. Med. – volume: 49 start-page: 34 year: 2000 end-page: 42 ident: bib31 article-title: Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip publication-title: Drug Development Research – volume: 24 start-page: 83 year: 2003 end-page: 98 ident: bib30 article-title: Review of proteomics with applications to genetic epidemiology publication-title: Genetic Epidemiology – volume: 66 start-page: 1 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib17 article-title: Some early history of membrane molecular biology publication-title: Ann. Rev. Physiology doi: 10.1146/annurev.physiol.66.032902.131835 – volume: 11 start-page: 561 year: 1999 ident: 10.1016/j.bbagen.2007.11.016_bib26 article-title: Mechanism of cell–cell adhesion complex assembly publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(99)00021-6 – volume: 23 start-page: 363 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib3 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 61 start-page: 2650 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib24 article-title: Study of the interaction of proteins with curcumin and SDS and its analytical application publication-title: Spectrochim. Acta A Mol. Biomol. Spectros. doi: 10.1016/j.saa.2004.10.007 – volume: 21 start-page: 81 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib19 article-title: Spectral and photophysical behaviours of curcumin and curcuminoids publication-title: Bull. Korean Chem. Soc. – volume: 64 start-page: 4270 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib32 article-title: Molecular causes of the aberrant choline phospholipid metabolism in breast cancer publication-title: Cancer Research doi: 10.1158/0008-5472.CAN-03-3829 – volume: 6 start-page: 933 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib5 article-title: Biological effects of curcumin and its role in cancer chemoprevention and therapy publication-title: Anticancer Agents Med. Chem. doi: 10.2174/187152006776930918 – volume: 59 start-page: 295 year: 1994 ident: 10.1016/j.bbagen.2007.11.016_bib18 article-title: Spectral and photochemical properties of curcumin publication-title: Photochem. Photobiol. doi: 10.1111/j.1751-1097.1994.tb05037.x – volume: 45 start-page: 49 year: 1997 ident: 10.1016/j.bbagen.2007.11.016_bib15 article-title: DNA staining for fluorescence and laser confocal microscopy publication-title: J. Histochem. Cytochem. doi: 10.1177/002215549704500107 – volume: 111 start-page: 161 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib22 article-title: Binding and distribution characteristics of curcumin solubilised in CTAB micelle publication-title: J. Mol. Liquids doi: 10.1016/j.molliq.2003.12.013 – volume: 77 start-page: 597 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib23 article-title: Photophysical studies on binding of curcumin to bovine serum albumin publication-title: Photochem. Photobiol. doi: 10.1562/0031-8655(2003)077<0597:PSOBOC>2.0.CO;2 – ident: 10.1016/j.bbagen.2007.11.016_bib10 – volume: 49 start-page: 34 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib31 article-title: Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip publication-title: Drug Development Research doi: 10.1002/(SICI)1098-2299(200001)49:1<34::AID-DDR6>3.0.CO;2-W – volume: 65 start-page: 55 year: 1983 ident: 10.1016/j.bbagen.2007.11.016_bib14 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(83)90303-4 – volume: 72 start-page: 625 year: 2000 ident: 10.1016/j.bbagen.2007.11.016_bib20 article-title: Effect of solvent on the excited state photophysical properties of curcumin publication-title: Photochem. Photobiol. doi: 10.1562/0031-8655(2000)072<0625:EOSOTE>2.0.CO;2 – volume: 130 start-page: 765 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib7 article-title: From exotic spice to modern drug publication-title: Cell doi: 10.1016/j.cell.2007.08.024 – volume: 273 start-page: 3003 year: 1998 ident: 10.1016/j.bbagen.2007.11.016_bib13 article-title: Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.5.3003 – volume: 43 start-page: 805 year: 1974 ident: 10.1016/j.bbagen.2007.11.016_bib16 article-title: The molecular organization of membranes publication-title: Ann. Rev. Biochem. doi: 10.1146/annurev.bi.43.070174.004105 – volume: 436 start-page: 239 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib25 article-title: Interaction of curcumin with human serum albumin: thermodynamic properties, fluorescence energy transfer and denaturation effects publication-title: Chem. Phys. Lett. doi: 10.1016/j.cplett.2007.01.006 – volume: 54 start-page: 2961 year: 1990 ident: 10.1016/j.bbagen.2007.11.016_bib11 article-title: Toxicity of dimethyl sulphoxide as a solvent in bioassay system with HeLa cells evaluated colorimetrically with 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide publication-title: Agric. Biol. Chem. doi: 10.1271/bbb1961.54.2961 – volume: 1056 start-page: 206 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib6 article-title: Curcumin: getting back to the roots publication-title: Ann. N.Y. Acad. Sci. doi: 10.1196/annals.1352.010 – volume: 47 start-page: 4992 year: 1999 ident: 10.1016/j.bbagen.2007.11.016_bib21 article-title: Interaction of curcumin with phosphatidylcholine: a spectrofluorometric study publication-title: J. Agric. Food Chem. doi: 10.1021/jf9900837 – volume: 87 start-page: 44 year: 2004 ident: 10.1016/j.bbagen.2007.11.016_bib2 article-title: Turmeric and curcumin: biological actions and medicinal applications publication-title: Curr. Sci. – volume: 1760 start-page: 1513 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib9 article-title: Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence study publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2006.06.012 – volume: 24 start-page: 83 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib30 article-title: Review of proteomics with applications to genetic epidemiology publication-title: Genetic Epidemiology doi: 10.1002/gepi.10226 – volume: 23 start-page: 838 year: 1997 ident: 10.1016/j.bbagen.2007.11.016_bib8 article-title: Free radical reactions of curcumin in membrane model publication-title: Free Radic. Biol. Med. doi: 10.1016/S0891-5849(97)00026-9 – volume: 8 start-page: 259 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib27 article-title: Mechanism and dynamics of cadherin adhesion publication-title: Ann. Rev. Biomed. Eng. doi: 10.1146/annurev.bioeng.8.061505.095753 – volume: 3 start-page: 1715 year: 2003 ident: 10.1016/j.bbagen.2007.11.016_bib12 article-title: Laser scanning confocal fluorescence microscopy: an overview publication-title: Int. Immunopharmacology doi: 10.1016/S1567-5769(03)00140-1 – start-page: 1 year: 2007 ident: 10.1016/j.bbagen.2007.11.016_bib1 article-title: Curcumin: the Indian solid gold – volume: 41 start-page: 1955 year: 2005 ident: 10.1016/j.bbagen.2007.11.016_bib4 article-title: Curcumin: the story so far publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2005.05.009 – volume: 51 start-page: 629 year: 2006 ident: 10.1016/j.bbagen.2007.11.016_bib28 article-title: Structure and function of cadherins publication-title: Tanpakushitsu Kakusan Koso – volume: 23 start-page: 912 year: 2001 ident: 10.1016/j.bbagen.2007.11.016_bib29 article-title: Leaving the neighborhood: molecular mechanisms involved during epithelial–mesenchymal transition publication-title: BioEssays doi: 10.1002/bies.1132
SSID	ssj0000595 ssj0025309
Score	2.4113245
Snippet	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was... Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	673
SubjectTerms	Animals Biological Transport Cell Line, Tumor Cell Membrane - metabolism Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Cellular uptake Curcuma - chemistry Curcumin Curcumin - metabolism Curcumin - pharmacokinetics Curcumin - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fluorescence Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Mice Microscopy, Confocal NIH 3T3 Cells Nuclear localization Spectrometry, Fluorescence Time Factors Tumor cell
Title	Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells
URI	https://dx.doi.org/10.1016/j.bbagen.2007.11.016 https://www.ncbi.nlm.nih.gov/pubmed/18178166 https://www.proquest.com/docview/70440225
Volume	1780
WOSCitedRecordID	wos000256211400005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1872-8006 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: AIEXJ dateStart: 19950118 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DgQvCMatXEYeeCuplqvtx2oaAqRNAw2pb5Ht2Fq2NalyGd1f4ldybCdtyhhjD0hV1FqO5eZ8ybnknPMh9D71pKJhkIKTE0k3lFHqMs7AS_GV72ufSBJlyCbw0RGZzejxYPCzq4W5vMB5TpZLuvivooYxELYunb2DuFeLwgB8B6HDEcQOx38S_NeG5aZyTOcE6bi8STRtFjWzeThGe7XVl7aq7aou6mKZiTY7QzSlaOaZSYHMtUlruwnUzbwozYLVxpvgrBCnmW46MJb1mGeFjZUw3aWDTbq21uOq4Tri03t1lP-wud3TyTqaWmbnm0OHWXVaWnbo1dg3nTCZs4rNbcrBZCNyQXoJL23FFgyAQRhtPI2xZXZqcRf2Hq6xJT1p9XRsSWiuqQAbjTibcA6zctukUvdp9f7Qcfs3TbjKT-xS384Su4om68TgLCUwuIW2fRxRMkTb088Hsy9rvR8Zjp_Vv-oKNU024fXd3GQI3eToGIPn5DF61HoqztQi7AkayHwH3bfcpVc76MF-RxX4FLE-5pwOc47F3AenjzgHoOT0EecUyukQ58DHIs5MM4gzy1XP0PePByf7n9yWu8MVYPPVroh5SFScBiFhIVeewlQoLwVnIU5THmHKPY8RgUMegHkUB74gsVJ-mFIiFSMseI6GeZHLl8ihMpSYSLBUAx4yFsBqnApO9yKJ6V6oRijoLmQi2sb2ml_lIvmbGEfIXZ21sI1dbpmPOxklrXFqjc4EgHfLme86kSYgF33VWC6Lpkqw5nsHhTpCL6yk1zshcB94cfzqjrt8jR6u77Q3aFiXjXyL7onLOqvKXbSFZ2S3xS38Ojo-_AVwSMqR
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quantitative+cellular+uptake%2C+localization+and+cytotoxicity+of+curcumin+in+normal+and+tumor+cells&rft.jtitle=Biochimica+et+biophysica+acta.+General+subjects&rft.au=Kunwar%2C+A.&rft.au=Barik%2C+A.&rft.au=Mishra%2C+B.&rft.au=Rathinasamy%2C+K.&rft.date=2008-04-01&rft.issn=0304-4165&rft.volume=1780&rft.issue=4&rft.spage=673&rft.epage=679&rft_id=info:doi/10.1016%2Fj.bbagen.2007.11.016&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bbagen_2007_11_016
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon