Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton

Phospholipase D activity has been extensively implicated in the regulation of the actin cytoskeleton. Through this regulation the enzyme controls a number of physiological functions such as cell migration and adhesion and, it also is implicated in the regulation of membrane trafficking. The two phos...

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Bibliographic Details
Published in:Biochimica et biophysica acta Vol. 1791; no. 9; pp. 856 - 861
Main Authors: Rudge, Simon A., Wakelam, Michael J.O.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.09.2009
Subjects:
Actin
Actins - metabolism
Animals
Cytoskeleton - metabolism
Enzyme Activation
Humans
Phosphatidic acid
Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol-4-phosphate-5-kinase
Phospholipase D
Phospholipase D - chemistry
Phospholipase D - metabolism
Protein Structure, Tertiary
Rho
Rho
Phosphatidylinositol-4-phosphate-5-kinase
Phosphatidylinositol 4,5-bisphosphate
Actin
Phospholipase D
Phosphatidic acid
ISSN:1388-1981, 0006-3002, 1879-2618
Online Access:Get full text
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Summary:Phospholipase D activity has been extensively implicated in the regulation of the actin cytoskeleton. Through this regulation the enzyme controls a number of physiological functions such as cell migration and adhesion and, it also is implicated in the regulation of membrane trafficking. The two phospholipase Ds are closely implicated with the control of the ARF and Rho families of small GTPases. In this article it is proposed that PLD2 plays the role of ‘master regulator’ and in an ill-defined manner regulates Rho function, PLD1 activity is downstream of this activation, however the generated phosphatidic acid controls changes in cytoskeletal organisation through its regulation of phosphatidylinositol-4-phosphate-5-kinase activity.
Bibliography:ObjectType-Article-1
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ObjectType-Review-3
content type line 23
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2009.04.008