Comparing Phylogenetic Approaches to Reconstructing Cell Lineage From Microsatellites With Missing Data

Due to the imperfect fidelity of DNA replication, somatic cells acquire DNA mutations at each division which record their lineage history. Microsatellites, tandem repeats of DNA nucleotide motifs, mutate more frequently than other genomic regions and by observing microsatellite lengths in single cel...

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Veröffentlicht in:	IEEE/ACM transactions on computational biology and bioinformatics Jg. 18; H. 6; S. 2291 - 2301
Hauptverfasser:	Lyne, Anne-Marie, Perie, Leila
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States IEEE 01.11.2021 The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Institute of Electrical and Electronics Engineers
Schlagworte:	Algorithms Animals Bayes methods Bioinformatics Cell division Cell lineage Cell Lineage - genetics Computational Biology - methods Computer applications Computer Science Deoxyribonucleic acid DNA DNA biosynthesis High-Throughput Nucleotide Sequencing Humans Mice Microsatellite Repeats - genetics Microsatellites Missing data Mutation Next-generation sequencing Nucleotides phylogenetic reconstruction Phylogenetics Phylogeny Probabilistic methods Progenitor cells Reconstruction Reconstruction algorithms Sequence Analysis, DNA Sequential analysis single cell Single-Cell Analysis Small satellites Somatic cells Topology Trees Trees (mathematics) microsatellites mutation Cell lineage single cell phylogenetic reconstruction
ISSN:	1545-5963, 1557-9964, 1557-9964
Online-Zugang:	Volltext
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