Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production...

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Bibliographic Details
Published in:	Critical care medicine Vol. 43; no. 3; p. e75
Main Authors:	van den Boogaard, Florry E, Schouten, Marcel, de Stoppelaar, Sacha F, Roelofs, Joris J T H, Brands, Xanthe, Schultz, Marcus J, van't Veer, Cornelis, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States 01.03.2015
Subjects:	Animals Antithrombin III - metabolism Cytokines - metabolism Disease Models, Animal Mice Peptide Hydrolases - metabolism Pneumonia, Pneumococcal - epidemiology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - pathology Purinergic P2Y Receptor Antagonists - pharmacology Streptococcus pneumoniae Thrombocytopenia - epidemiology Thrombocytopenia - immunology Thrombocytopenia - pathology Ticlopidine - analogs & derivatives Ticlopidine - pharmacology
ISSN:	1530-0293, 1530-0293
Online Access:	Get more information
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