Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1

The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall 1 , 2 . FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp 3 , 4 . Unfortunately, the mechanism of action of FKS remains eni...

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Bibliographic Details
Published in:	Nature (London) Vol. 616; no. 7955; pp. 190 - 198
Main Authors:	Hu, Xinlin, Yang, Ping, Chai, Changdong, Liu, Jia, Sun, Huanhuan, Wu, Yanan, Zhang, Mingjie, Zhang, Min, Liu, Xiaotian, Yu, Hongjun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.04.2023 Nature Publishing Group
Subjects:	101/28 631/326/193 631/45/221 631/535/1258/1259 82/16 82/80 82/83 Antifungal agents Antifungal Agents - pharmacology beta-Glucans - metabolism Biosynthesis Catalytic Domain Cell Membrane - chemistry Cell Membrane - metabolism Cryoelectron Microscopy Cytoplasm Drug delivery Drug resistance Drug Resistance, Fungal - drug effects Drug Resistance, Fungal - genetics Drugs Echinocandins Echinocandins - pharmacology Electron microscopy Enzymes Fungi Fungicides Glucan Glucosyltransferases - antagonists & inhibitors Glucosyltransferases - chemistry Glucosyltransferases - genetics Glucosyltransferases - metabolism Glucosyltransferases - ultrastructure Humanities and Social Sciences Lipids Membranes Microbial Sensitivity Tests Microscopy multidisciplinary Mutation Polymers Resistant mutant Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Science (multidisciplinary) Translocation β-1,3-Glucan
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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