Polymorphism of the Androgen Receptor Gene is Associated with Male Pattern Baldness

The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the...

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Vydáno v:	Journal of investigative dermatology Ročník 116; číslo 3; s. 452 - 455
Hlavní autoři:	Ellis, Justine A., Stebbing, Margaret, Harrap, Stephen B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Danvers, MA Elsevier Inc 01.03.2001 Nature Publishing Elsevier Limited
Témata:	Adult alopecia Alopecia - classification Alopecia - epidemiology Alopecia - genetics androgens Australia Biological and medical sciences Dermatology Exons genetics Hair and nails disorders hair loss Humans Incidence Male Medical sciences Middle Aged Phenotype Polymorphism, Genetic Polymorphism, Restriction Fragment Length Receptors, Androgen - genetics Reference Values testosterone Trinucleotide Repeats Australia hair loss genetics alopecia androgens testosterone Hair (head) Human Skin disease Androgen Gene Genetics Sex steroid hormone Androgenetic alopecia Polymorphism Hormonal receptor
ISSN:	0022-202X, 1523-1747
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Popis
Shrnutí:	The common heritable loss of scalp hair known as male pattern baldness or androgenetic alopecia affects up to 80% of males by age 80. A balding scalp is characterized by high levels of the potent androgen dihydrotestosterone and increased expression of the androgen receptor gene. To determine if the androgen receptor gene is associated with male pattern baldness, we compared allele frequencies of the androgen receptor gene polymorphisms (StuI restriction fragment length polymorphism and two triplet repeat polymorphisms) in cases with cosmetically significant baldness (54 young and 392 older men) and controls (107 older men) with no indication of baldness. The androgen receptor gene StuI restriction site was found in all but one (98.1%) of the 54 young bald men (p =0.0005) and in 92.3% of older balding men (p =0.000004) but in only 76.6% of nonbald men. The combination of shorter CAG and GGC triplet repeat lengths was also more prevalent in bald men (p =0.03). The ubiquity of the androgen receptor gene StuI restriction site, and higher incidence of shorter triplet repeat haplotypes in bald men suggests that these markers are very close to a functional variant that is a necessary component of the polygenic determination of male pattern baldness. Functional mutation in or near the androgen receptor gene may explain the reported high levels of expression of this gene in the balding scalp.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0022-202X 1523-1747
DOI:	10.1046/j.1523-1747.2001.01261.x